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Generic Name: esterified estrogens (ess TER ih fied ESS troe jenz)
Brand Names: Estratab, Menest

What are esterified estrogens?

Estrogen is a female sex hormone necessary for many processes in the body.

Esterified estrogens are naturally occurring female sex hormones that are used to treat symptoms of menopause; deficiency in ovary function (including underdevelopment of female sexual characteristics and some types of infertility); some types of breast cancer in men and in postmenopausal women; degeneration of the vagina; and urethra and prostate cancer. In addition, esterified estrogens are used to prevent osteoporosis.

Esterified estrogens may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about esterified estrogens?

Esterified estrogens increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with esterified estrogens lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away.

Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking esterified estrogens.

Who should not take esterified estrogens?

• a circulation, bleeding, or blood-clotting disorder;

• undiagnosed, abnormal vaginal bleeding; or

• any type of breast, uterine, or hormone-dependent cancer.

Taking esterified estrogens may be dangerous in some cases if you have any of the conditions listed above.

Before taking esterified estrogens, tell your doctor if you have

• high blood pressure, angina, or heart disease;

• high levels of cholesterol or triglycerides in your blood;

• liver disease;
• kidney disease;

• asthma;

• epilepsy;

• migraines;

• diabetes;

• depression;

• gallbladder disease;

• uterine fibroids; or

• had a hysterectomy (uterus removed).

You may not be able to take esterified estrogens, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take esterified estrogens?

Take this medication exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Try to take every dose at the same time each day. You may be taking it every day, or you may be taking it every day for 3 weeks with 1 week off each month to mimic your body's natural cycle. Follow the directions on your prescription label.

If you are taking esterified estrogens to treat cancer, you may be taking it several times a day in very large doses.

Have yearly physical exams and examine your breasts for lumps on a monthly basis while taking esterified estrogens.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

Symptoms of an overdose of esterified estrogens include nausea, vomiting, and breakthrough bleeding in females.

What should I avoid while taking esterified estrogens?

There are no restrictions on food, beverages, or activity while taking esterified estrogens unless your doctor directs otherwise.

Esterified estrogens side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• a blood clot (pain, redness, and swelling in an arm or leg, shortness of breath, chest pain, headache, blurred vision, or confusion);

• a lump in a breast; or

• liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue).

Other, less serious side effects may be more likely to occur. Continue to take esterified estrogens and talk to your doctor if you experience

• decreased appetite, nausea, or vomiting;

• swollen or tender breasts;

• acne or skin color changes;

• decreased sex drive;

• migraine headaches or dizziness;

• water retention (swollen hands, feet, or ankles);

• problems with wearing contact lenses;

• depression; or

• changes in your menstrual cycle or breakthrough bleeding.

Esterified estrogens increase the risk of developing a condition (endometrial hyperplasia) that may lead to cancer of the lining of the uterus. Taking progestins, another hormone drug, with esterified estrogens lowers the risk of developing this condition. Therefore, if your uterus has not been removed, your doctor may prescribe a progestin for you to take together with the estrogen. Visit your doctor regularly and report any unusual vaginal bleeding right away.

It is unclear to what extent estrogen treatments may affect the risk of breast cancer.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect esterified estrogens?

Before taking esterified estrogens, tell your doctor if you are taking any of the following medicines:

• an anticoagulant (blood thinner) such as warfarin (Coumadin);

• a thyroid medication such as Synthroid, Levoxyl, Levothroid, and others;

• insulin or an oral diabetes medicine such as glipizide (Glucotrol) or glyburide (Diabeta, Micronase);

• tamoxifen (Nolvadex);

• didanosine (Videx);

• phenytoin (Dilantin) or ethotoin (Peganone);

• carbamazepine (Tegretol);

• phenobarbital (Solfoton, Luminal);

• primidone (Mysoline); or

• rifampin (Rifadin).

A dosage adjustment or special monitoring may be required during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with esterified estrogens. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about esterified estrogens written for health professionals that you may read.

What does my medication look like?

Esterified estrogens are available with a prescription under the brand names Menest and Estratab. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Menest 0.3 mg--yellow, oblong, film-coated tablets

• Menest 0.625 mg--orange, oblong, film-coated tablets

• Menest 1.25 mg--green, oblong, film-coated tablets

• Menest 2.5 mg--pink, oblong, film-coated tablets

• Estratab 0.3 mg--blue, round tablets

• Estratab 0.625 mg--yellow, round tablets

• Estratab 1.25 mg--orange-red, round tablets

• Estratab 2.5 mg--light-purple, round tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.