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Generic Name: guaifenesin and hydrocodone (gwye FEH ne sin and high droe KOE dohn )
Brand Names: Atuss HX, Co-Tussin, Codotuss, Cotuss V, Entuss, Fentuss Expectorant, G-Tuss, Gua HC, Hycoclar Tuss, Hycoclear, Hycosin Expectorant, Hycotuss Expectorant, Hydrotuss, Kwelcof, Medcodin, Pneumotussin 2.5, Propatuss Expectorant, Tusso-DF, Vicoclear, Vicodin Tuss, Vicotuss, Vitussin Expectorant, Vortex

What is Entuss (guaifenesin and hydrocodone)?

Guaifenesin is an expectorant. Guaifenesin loosens phlegm and increases the lubrication of the lungs allowing for a productive cough and decreased chest congestion.

Hydrocodone is a narcotic. It is a pain reliever and a cough suppressant.

Guaifenesin and hydrocodone is used to treat cough and nasal congestion associated with the common cold, allergies and infections.

Guaifenesin and hydrocodone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Entuss (guaifenesin and hydrocodone)?

Guaifenesin and hydrocodone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other medicine without first talking to your doctor.

What should I discuss with my healthcare provider before taking Entuss (guaifenesin and hydrocodone)?

Hydrocodone is habit forming and should only be used under close supervision by patients with past or current alcohol or drug addiction.

Before taking this medication, tell your doctor if you have

• kidney disease;
• liver disease;

• asthma;

• urinary retention;

• an enlarged prostate;

• hypothyroidism;

• seizures or epilepsy;

• gallbladder disease;

• a head injury; or

• Addison's Disease.

You may not be able to take guaifenesin and hydrocodone, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take Entuss (guaifenesin and hydrocodone)?

Take guaifenesin and hydrocodone exactly as directed by your doctor. If you do not understand the directions on your prescription bottle, ask your pharmacist, nurse, or doctor to explain the instructions to you.

Guaifenesin and hydrocodone can be taken with or without food.

To ensure that you get a correct dose, measure the liquid form of guaifenesin and hydrocodone with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of a guaifenesin and hydrocodone overdose may include extreme drowsiness, dizziness, headache, seizures, dry mouth, cold and clammy skin, flushing, nausea, vomiting, difficult or decreased breathing, and unconsciousness.

What should I avoid while taking Entuss (guaifenesin and hydrocodone)?

Guaifenesin and hydrocodone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other medicine without first talking to your doctor.

Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medications while taking guaifenesin and hydrocodone without first talking to your pharmacist or doctor. Other medications may also contain hydrocodone, guaifenesin or other similar drugs, and you may accidentally take too much of these medicines.

Entuss (guaifenesin and hydrocodone) side effects

• a rare but serious allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or

• confusion, hallucinations, or unusual behavior.

Other, less serious side effects may be more likely to occur. Continue to take guaifenesin and hydrocodone and talk to your doctor if you experience

• dizziness, drowsiness, or sleepiness;

• restlessness or irritability;

• blurred vision;

• constipation;

• dry mouth;

• nausea, vomiting, or decreased appetite;

• muscle twitches;

• sweating;

• itching; or

• decreased urination.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Entuss (guaifenesin and hydrocodone)?

Guaifenesin and hydrocodone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medications while taking guaifenesin and hydrocodone without first talking to your pharmacist or doctor. Other medications may also contain hydrocodone, guaifenesin, or other similar drugs, and you may accidentally take too much of these medicines.

Drugs other than those listed here may also interact with guaifenesin and hydrocodone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

• Your pharmacist has more information about guaifenesin and hydrocodone written for health professionals that you may read.

What does my medicine look like?

Guaifenesin and hydrocodone is available with a prescription under the brand names Vicodin Tuss and Vicotuss. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.