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Generic Name: carbinoxamine, hydrocodone, and phenylephrine (kar bi NOX a meen, hy dro KOE done, fen il EFF rin)
Brand Names: Donatussin MAX, Excof, Excof-SF

What is Donatussin MAX (carbinoxamine, hydrocodone, and phenylephrine)?

Carbinoxamine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is a narcotic cough suppressant. It suppresses an area in the brain that causes coughing.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Carbinoxamine, hydrocodone, and phenylephrine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

This medication may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Donatussin MAX (carbinoxamine, hydrocodone, and phenylephrine)?

Call your doctor if you have a fever, or if your symptoms get worse or do not improve after taking this medicine for 7 days.

Do not take this product for cough caused by smoking, asthma, or emphysema. Do not take this medicine if your cough produces a lot of mucus, unless your doctor has told you to.

What should I discuss with my health care provider before taking Donatussin MAX (carbinoxamine, hydrocodone, and phenylephrine)?

Before taking this medication, tell your doctor if you are allergic to carbinoxamine, hydrocodone, or phenylephrine, or if you have:

• a history of drug or alcohol addiction;

• kidney disease;
• liver disease;

• diabetes;

• glaucoma;

• heart disease or high blood pressure;

• coronary artery disease;

• a stomach ulcer or an obstruction in your stomach or intestines;

• an enlarged prostate or urination problems;

• head injury, brain injury, or brain tumor;

• Addison's disease;

• thyroid problems;

• emphysema or chronic bronchitis;

• asthma.

If you have any of these conditions, you may not be able to take this medication, or you may require a dosage adjustment or special monitoring during treatment.

How should I take Donatussin MAX (carbinoxamine, hydrocodone, and phenylephrine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

You may take this medication with or without food.

Measure the liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Call your doctor if you have a fever, or if your symptoms get worse or do not improve after taking this medicine for 7 days.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Symptoms of an overdose may include dizziness, ringing in the ears, blurred vision, large pupils, dry mouth, a weak heartbeat, extreme drowsiness, sweating, shaking, pale skin, blue lips and fingernails, hallucinations, confusion, seizures, shallow breathing, coma, and death.

What should I avoid while taking Donatussin MAX (carbinoxamine, hydrocodone, and phenylephrine)?

Avoid using other medicines that make you sleepy (such as cold medicine, other narcotics, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by carbinoxamine, hydrocodone, and phenylephrine.

Donatussin MAX (carbinoxamine, hydrocodone, and phenylephrine) side effects

• seizure (convulsions);

• unusual behavior or hallucinations;

• an irregular or fast heartbeat;

• feeling light-headed, fainting;

• urinating less than usual or not at all;

• wheezing, tightness in your chest;

• fast or pounding heartbeat;

• jaundice (yellowing of the skin or eyes);

• pale skin, easy bruising or bleeding;

• slow or weak breathing; or

• swelling, rapid weight gain.

Continue taking this medication and talk to your doctor if you have any of these less serious side effects:

• drowsiness, dizziness;

• lack of coordination;

• upset stomach, nausea, stomach cramps, or constipation;

• stuffy nose, chest congestion;

• sleep problems (insomnia);

• itchy skin rash;

• decreased hearing or ringing in the ears;

• feeling restless or excited (especially in children);

• dry mouth or nose; or

• blurred vision.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Donatussin MAX (carbinoxamine, hydrocodone, and phenylephrine)?

Before taking carbinoxamine, hydrocodone, and phenylephrine, tell your doctor if you are taking any of the following medicines:

• medicine to treat high blood pressure or a heart condition;

• medicine to treat diabetes;

• weight loss medication;

• another decongestant (cold or allergy product); or

• antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

If you are using any of these drugs, you may not be able to use carbinoxamine, hydrocodone, and phenylephrine or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect carbinoxamine, hydrocodone, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has additional information about carbinoxamine, hydrocodone, and phenylephrine written for health professionals that you may read.

What does my medication look like?

Carbinoxamine, hydrocodone, and phenylephrine is available with a prescription under the brand names Donatussin and Excof. Other brand and generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.