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Diphenhydramine Solution is used for:

Treating allergic reactions, allergy symptoms, motion sickness, and Parkinson disease when treatment with medicine taken by mouth is not possible. It may also be used to treat certain conditions as determined by your doctor.

Diphenhydramine Solution is an antihistamine and anticholinergic. It works by blocking the action of histamine, which reduces the symptoms of an allergic reaction. It also works in the brain to reduce symptoms of Parkinson disease and motion sickness.

Do NOT use Diphenhydramine Solution if:

• you are allergic to any ingredient in Diphenhydramine Solution or to similar medicines
• you are taking sodium oxybate (GHB)
• you are taking or have taken a monoamine oxidase (MAO) inhibitor (eg, phenelzine) in the past 2 weeks
• you are breast-feeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Diphenhydramine Solution:

Some medical conditions may interact with Diphenhydramine Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant or planning to become pregnant
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, lung disease, shortness of breath, or sleep apnea
• if you have blockage of the stomach, intestine, or urinary tract; difficulty urinating; diabetes; ulcers; enlargement of the prostate; glaucoma; heart disease; high blood pressure; porphyria; or thyroid disease

Some MEDICINES MAY INTERACT with Diphenhydramine Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur
• MAO inhibitors (eg, phenelzine) because they can cause serious, possibly life-threatening, reactions. Do NOT take MAO inhibitors within 2 weeks of taking Diphenhydramine Solution.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diphenhydramine Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Diphenhydramine Solution:

Use Diphenhydramine Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Diphenhydramine Solution is for injection only.
• Diphenhydramine Solution is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Diphenhydramine Solution at home, carefully follow the injection procedures taught to you by your health care provider.
• If Diphenhydramine Solution contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for proper disposal.
• If you miss a dose of Diphenhydramine Solution and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Diphenhydramine Solution.

Important safety information:

• Diphenhydramine Solution may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Diphenhydramine Solution. Using Diphenhydramine Solution alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Diphenhydramine Solution. Diphenhydramine Solution will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• Alcohol, hot weather, exercise, and fever can increase the risk of dizziness, lightheadedness, or fainting. To prevent these effects, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
• Do not become overheated in hot weather or during exercise or other activities because heatstroke may occur.
• Diphenhydramine Solution may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Diphenhydramine Solution. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
• Diphenhydramine Solution contains diphenhydramine. Before you begin taking any new prescription or over-the-counter medicine, including one used on the skin, read the ingredients to see if it also contains diphenhydramine. If it does or if you are uncertain, contact your doctor or pharmacist.
• Use Diphenhydramine Solution with caution in the ELDERLY because they may be more sensitive to its effects, especially dizziness, sedation, and lightheadedness upon standing.
• Diphenhydramine Solution is not recommended for use in PREMATURE INFANTS or NEWBORN INFANTS younger than 4 weeks of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Diphenhydramine Solution during pregnancy. Diphenhydramine Solution is excreted in breast milk. Do not breast-feed while taking Diphenhydramine Solution.

Possible side effects of Diphenhydramine Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, throat, and nose; thickening of mucus in nose or throat.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); convulsions; decreased alertness; excitability; fast heartbeat; hallucinations; pain, redness, or swelling at the injection site; tightness or pounding in the chest; tremor; wheezing.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include coma; excitement; hallucinations; loss of consciousness; muscle twitching; seizures; tremor; weakness.

Store Diphenhydramine Solution at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not freeze. Do not store in the bathroom. Keep Diphenhydramine Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Diphenhydramine Solution, please talk with your doctor, pharmacist, or other health care provider.
• Diphenhydramine Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Diphenhydramine Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.