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Some commonly used brand names are:

In the U.S.—

• Rimso-50

In Canada—

• Rimso-50

Generic name product may be available in the U.S.

Another commonly used name is DMSO .

Category

• Anti-inflammatory, local, interstitial cystitis

Description

Dimethyl sulfoxide (dye-METH-il sul-FOX-ide) is a purified preparation used in the bladder to relieve the symptoms of the bladder condition called interstitial cystitis. A catheter (tube) or syringe is used to put the solution into the bladder where it is allowed to remain for about 15 minutes. Then, the solution is expelled by urinating.

Interstitial cystitis is the only human use for dimethyl sulfoxide that is approved by the U.S. Food and Drug Administration (FDA).

Claims that dimethyl sulfoxide is effective for treating various types of arthritis, ulcers in scleroderma, muscle sprains and strains, bruises, infections of the skin, burns, wounds, and mental conditions have not been proven.

Although other preparations of dimethyl sulfoxide are available for industrial and veterinary (animal) use, they must not be used by humans, because of their unknown purity. Impurities in these preparations may cause serious unwanted effects in humans. Even if dimethyl sulfoxide is applied to the skin, it is absorbed into the body through the skin and mucous membranes.

This medicine is available only with your doctor's prescription, in the following dosage form:

• Topical
• Bladder irrigation (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dimethyl sulfoxide, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to dimethyl sulfoxide. Also tell your health care professional if you are allergic to any other substances, such as preservatives.

Pregnancy—Dimethyl sulfoxide has not been studied in pregnant women. However, some studies in animals have shown that dimethyl sulfoxide causes birth defects when used on the skin and when given in high doses by injection. Before using this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—Dimethyl sulfoxide is absorbed into the body. It is not known whether dimethyl sulfoxide passes into the breast milk. However, this medicine has not been reported to cause problems in nursing babies.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of this medicine in children with use in other age groups.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this medicine in the elderly with use in other age groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Proper Use of This Medicine

Dosing—The dose of dimethyl sulfoxide will be different for different patients. The following information includes only the average doses of dimethyl sulfoxide. Your dose may be different .

• For bladder irrigation dosage form:
  • For interstitial cystitis of bladder:
    • Adults—50 mL (milliliters) of a 50% solution is instilled into the bladder and left there for fifteen minutes. The treatment is repeated every two weeks until relief is obtained; then the treatment is repeated less often.
    • Children—Use and dose must be determined by your doctor.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Some patients may have some discomfort during the time this medicine is being put into the bladder. However, the discomfort usually becomes less each time the medicine is used.

Dimethyl sulfoxide may cause you to have a garlic-like taste within a few minutes after the medicine is put into the bladder. This effect may last for several hours. It may also cause your breath and skin to have a garlic-like odor, which may last up to 72 hours.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 03/28/1994

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