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Generic Name: diazepam rectal (dye AZ e pam)
Brand Names: Diastat, Diastat AcuDial, Diastat Pediatric

What is Diastat Pediatric (diazepam rectal)?

Diazepam rectal is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Diazepam rectal affects chemicals in the brain that may become unbalanced and cause seizure.

Diazepam rectal is used to treat occasionally increased seizures in people with epilepsy who also routinely take other anti-convulsants. Diazepam rectal is not for long-term daily use to prevent seizures.

Diazepam rectal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Diastat Pediatric (diazepam rectal)?

Before using diazepam rectal, tell your doctor if you have any breathing problems, glaucoma, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Avoid using other medicines that make you sleepy. They can add to sleepiness caused by diazepam rectal.

What should I discuss with my healthcare provider before using Diastat Pediatric (diazepam rectal)?

Before using diazepam rectal, tell your doctor if you are allergic to any drugs, or if you have:

• glaucoma;

• asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;

• kidney or liver disease;

• a history of depression or suicidal thoughts or behavior; or

• a history of drug or alcohol addiction.

If you have any of these conditions, you may not be able to use diazepam rectal, or you may need a dosage adjustment or special tests during treatment.

How should I use Diastat Pediatric (diazepam rectal)?

Use this medication exactly as it was prescribed. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on the prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Diazepam rectal is used in combination with other seizure medications. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

Diazepam rectal is not for long-term daily use to prevent seizures. Using diazepam rectal daily over long periods can actually make your seizures more frequent or more severe. You may also have withdrawal symptoms (such as tremors, stomach pain, muscle cramps, vomiting, and increased sweating) when you stop using diazepam rectal.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Symptoms of a diazepam rectal overdose may include extreme drowsiness, confusion, muscle weakness, fainting, or coma.

What should I avoid while using Diastat Pediatric (diazepam rectal)?

Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, or muscle relaxers). They can increase some of the side effects of diazepam rectal.

Diastat Pediatric (diazepam rectal) side effects

• worsening seizures, or seizures that seem different from the patient's other seizures;

• pale or discolored skin;

• confusion, unusual thoughts or behavior;

• unusual risk-using behavior, decreased inhibitions, no fear of danger;

• depressed mood, thoughts of suicide or hurting yourself;

• hyperactivity, agitation, hostility;

• hallucinations;

• feeling light-headed, fainting; or

• pain or burning with urination.

Less serious side effects are more likely to occur, such as:

• drowsiness, tiredness;

• blurred vision;

• sleep problems (insomnia);

• muscle weakness, lack of balance or coordination;

• slurred speech;

• nausea, vomiting, stomach pain, diarrhea;

• headache;

• skin rash; or

• runny nose.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Diastat Pediatric (diazepam rectal)?

Before using diazepam rectal, tell your doctor if you are using any of the following drugs:

• cimetidine (Tagamet);

• valproate (Depakene);

• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);

• an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);

• medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);

• narcotic medications such as butorphanol (Stadol), codeine, hydrocodone (Loratab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet); or

• antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).

If you are using any of these drugs, you may not be able to use diazepam rectal, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect diazepam rectal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about diazepam rectal written for health professionals that you may read.

What does my medication look like?

Diazepam rectal is available with a prescription under the brand name Diastat. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are using, check with your doctor, nurse or pharmacist.