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Generic Name: dalfopristin and quinupristin (dal FOE pris tin and kwi NYOO pris tin)
Brand Names:

What is dalfopristin and quinupristin?

Dalfopristin and quinupristin is a combination antibiotic that fights severe or life-threatening infection caused by bacteria.

Dalfopristin and quinupristin is used to treat severe infections in the blood and other body systems.

Dalfopristin and quinupristin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about dalfopristin and quinupristin?

Before receiving dalfopristin and quinupristin, tell your doctor if you have liver or kidney disease, or a history of any type of allergy.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

What should I discuss with my health care provider before receiving dalfopristin and quinupristin?

Before receiving dalfopristin and quinupristin, tell your doctor if you are allergic to any drugs, or if you have:

• liver disease;

• kidney disease; or

• a history of any type of allergy.

If you have any of these conditions, you may not be able to receive dalfopristin and quinupristin, or you may need a dosage adjustment or special tests during treatment.

How is dalfopristin and quinupristin given?

Dalfopristin and quinupristin is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection.

Dalfopristin and quinupristin is most often given in a hospital setting. The medicine must be given slowly through an IV infusion, and can take up to 1 hour or longer to complete.

Dalfopristin and quinupristin is usually given for at least 7 days, or longer for more severe infections.

What happens if I miss a dose?

Since this medicine is usually given in a hospital, it is not likely that you will miss a dose.

What happens if I overdose?

Symptoms of a dalfopristin and quinupristin overdose may include vomiting, trouble breathing, tremors, shaking, and loss of balance or coordination.

What should I avoid while taking dalfopristin and quinupristin?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Dalfopristin and quinupristin side effects

• diarrhea that is watery or bloody;

• jaundice (yellowing of the skin or eyes);

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

• confusion, seizure (convulsions);

• feeling light-headed, fainting;

• pale skin, easy bruising or bleeding, unusual weakness; or

• fever, chills, body aches, or other flu symptoms.

Less serious side effects may be more likely to occur, such as:

• joint or muscle pain;

• mild skin rash or itching;

• nausea, vomiting, constipation;

• headache, dizziness, confusion;

• sleep problems (insomnia);

• vaginal itching or discharge; or

• pain, swelling, or irritation where the IV needle is placed.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect dalfopristin and quinupristin?

Before receiving dalfopristin and quinupristin, tell your doctor if you are using any of the following drugs:

• astemizole (Himanal), cisapride (Propulsid), or terfenadine (Seldane);

• cyclosporine (Gengraf, Neoral, Sandimmune);

• digoxin (digitalis, Lanoxin);

• diazepam (Valium) or midazolam (Versed);

• methylprednisolone (Medrol, Duralone, Medipred, and others);

• cyclosporine (Gengraf, Neoral, Sandimmune), tacrolimus (Prograf);

• cancer medications such as vinblastine (Velban), vincristine (Oncovin), vinorelbine (Navelbine), docetaxel (Taxotere), paclitaxel (Taxol);

• a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan);

• HIV or AIDS medications such as delavirdine (Rescriptor), indinavir (Crixivan), nevirapine (Viramune), or ritonavir (Norvir); or

• heart rhythm medications such as disopyramide (Norpace), lidocaine, or quinidine (Quinaglute, Quinidex).

If you are using any of these drugs, you may not be able to receive dalfopristin and quinupristin, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect dalfopristin and quinupristin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your doctor or pharmacist has information about dalfopristin and quinupristin written for health professionals that you may read.

• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.