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Some commonly used brand names are:

In the U.S.—

• Ak-Spore H.C. Ophthalmic Suspension
• Cortisporin Ophthalmic Suspension

In Canada—

• Cortisporin Eye/Ear Suspension

Generic name product may be available in the U.S.

Category

• Anti-inflammatory (steroidal), ophthalmic
• corticosteroid (ophthalmic)
• antibacterial ophthalmic

Description

Neomycin, polymyxin B, and hydrocortisone (nee-oh-MYE-sin, pol-i-MIX-in bee, and hye-droe-KOR-ti-sone) is a combination antibiotic and cortisone-like medicine. It is used to treat infections of the eye and to help provide relief from redness, irritation, and discomfort of certain eye problems. It is also used to help prevent permanent damage of certain eye problems.

Neomycin, polymyxin B, and hydrocortisone combination is available only with your doctor's prescription, in the following dosage form:

• Ophthalmic
• Ophthalmic suspension (eye drops) (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For neomycin, polymyxin B, and hydrocortisone ophthalmic drops, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or to any related antibiotic, such as amikacin (e.g., Amikin), colistimethate (e.g., Coly-Mycin M), colistin (e.g., Coly-Mycin S), gentamicin (e.g., Garamycin), kanamycin (e.g., Kantrex), netilmicin (e.g., Netromycin), paromomycin (e.g., Humatin), streptomycin, or tobramycin (e.g., Nebcin). Also tell your health care professional if you are allergic to any other substances, such as preservatives.

Pregnancy—Neomycin, polymyxin B, and hydrocortisone ophthalmic preparations have not been studied in pregnant women. However, studies in animals have shown that topical corticosteroids cause birth defects. Before using this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known how much ophthalmic neomycin, polymyxin B, and hydrocortisone ophthalmic drops is absorbed into the body, or how much passes into breast milk. Discuss with your doctor whether or not you should breast-feed during treatment with this medicine.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use in children with use in other age groups.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of ophthalmic neomycin, polymyxin B, and hydrocortisone combination in the elderly with use in other age groups.

Other medical problems—The presence of other medical problems may affect the use of neomycin, polymyxin B, and hydrocortisone ophthalmic drops. Make sure you tell your doctor if you have any other medical problems, especially:

• Any other eye infection or condition or
• Glaucoma—Use of neomycin, polymyxin B, and hydrocortisone ophthalmic drops may make the condition worse

• Cataract surgery, recent—Use of neomycin, polymyxin B, and hydrocortisone ophthalmic drops may delay healing or cause other problems

Proper Use of This Medicine

The bottle is only partially full to provide proper drop control.

To use:

• First, wash your hands. Then tilt the head back and pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close the eyes. Do not blink. Keep the eyes closed for 1 or 2 minutes to allow the medicine to come into contact with the infection.
• If you think you did not get the drop of medicine into your eye properly, use another drop.
• To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed.

To help clear up your infection completely, keep using this medicine for the full time of treatment , even if your symptoms have disappeared. Do not miss any doses .

Dosing—The dose of ophthalmic neomycin, polymyxin B, and hydrocortisone combination will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of ophthalmic neomycin, polymyxin B, and hydrocortisone combination. If your dose is different, do not change it unless your doctor tells you to do so.

The number of doses you use each day, the time allowed between doses, and the length of time you use the medicine depend on the medical problem for which you are using ophthalmic neomycin, polymyxin B, and hydrocortisone combination .

• For eye infection:
  • For ophthalmic suspension dosage forms:
    • Adults—One or two drops every three or four hours.
    • Children—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage—To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Keep the medicine from freezing.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

If you will be using this medicine for more than 10 days, your doctor should check your eyes at regular visits.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

If a rash or allergic reaction develops, you should check with your doctor right away.

You should not let anyone else use your medicine. It could cause infection to spread.

Do not use any leftover medicine for future eye problems without checking with your doctor first . This medicine should not be used on many different kinds of infection.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop using this medicine and get emergency help immediately if any of the following side effects occur:

Check with your doctor immediately if any of the following side effects occur:

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if either of the following side effects continues or is bothersome:

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 02/15/2005

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