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Cimetidine Solution is used for:

Treating and preventing ulcers of the stomach and small intestine, and relieving symptoms associated with conditions that cause increased acid secretion (eg, Zollinger-Ellison syndrome) in patients who cannot take or do not respond to oral medicine. It is also used for preventing stomach bleeding in critically ill patients. It may also be used for other conditions as determined by your doctor.

Cimetidine Solution is an H₂ (histamine) blocker. It works by blocking one of the chemicals, histamine, that stimulates the release of acid into the stomach. This reduces acidity in the stomach.

Do NOT use Cimetidine Solution if:

• you are allergic to any ingredient in Cimetidine Solution
• you are taking cisapride, dofetilide, or a nitrosoureas (eg, carmustine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cimetidine Solution:

Some medical conditions may interact with Cimetidine Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have liver or kidney problems

Some MEDICINES MAY INTERACT with Cimetidine Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Many prescription medicines (eg, those used for angina, asthma, arrhythmias, blood thinning, cancer, erectile dysfunction, high blood pressure, infections, pain, psychiatric disorders, seizures, other conditions) because their actions and side effects, some potentially life-threatening, may be increased by Cimetidine Solution.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cimetidine Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cimetidine Solution:

Use Cimetidine Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Cimetidine Solution is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Cimetidine Solution at home, carefully follow the injection procedures taught to you by your health care provider.
• If Cimetidine Solution contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• If you are taking a cephalosporin (eg, cephalexin), itraconazole, or ketoconazole, you should take them at least 2 hours before Cimetidine Solution.
• Keep this product, as well as all syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for proper disposal.
• If you miss a dose of Cimetidine Solution, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cimetidine Solution.

Important safety information:

• Cimetidine Solution may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Cimetidine Solution. Using Cimetidine Solution alone, with other medicines, or with alcohol, may lessen your ability to drive or to perform other potentially dangerous tasks.
• It may be necessary to make significant lifestyle changes to assist in the treatment and prevention of ulcers and other digestive problems that include stress-reduction programs, exercise, and dietary changes.
• If your symptoms do not improve within a few days, or if they become worse, check with your doctor.
• Never self-diagnose or self-treat ulcers with this or any other medicine.
• Notify your doctor if you experience black, tarry stools or vomit that looks like coffee grounds.
• Do not drink alcohol while you are using Cimetidine Solution.
• Do not smoke or use other tobacco products while using Cimetidine Solution.
• Additional monitoring of your dose or condition may be necessary if you are also taking zaleplon.
• Use Cimetidine Solution with caution in the ELDERLY because they may be more sensitive to its effects.
• Use Cimetidine Solution with extreme caution in CHILDREN younger than 16 years of age. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Cimetidine Solution during pregnancy. Cimetidine Solution is excreted in breast milk. Do not breast-feed while taking Cimetidine Solution.

Possible side effects of Cimetidine Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; headache.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; anxiety; breast enlargement; breast lumps; confusion; depression; disorientation; fatigue; hallucinations; hair loss; joint or muscle pain; pain, redness or swelling at injection site; skin flushing or redness; sexual difficulties; slow or fast heartbeat.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include difficulty breathing; fast heartbeat; restlessness; tremors; vomiting.

Store the undiluted or premixed solution between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, light, and moisture. Cimetidine Solution is stable for 48 hours at room temperature when added to commonly used injection solutions. Keep Cimetidine Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Cimetidine Solution, please talk with your doctor, pharmacist, or other health care provider.
• Cimetidine Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Cimetidine Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.