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Generic Name: oxtriphylline (ox TRYE fi lin)
Brand Names: Choledyl, Choledyl SA

What is Choledyl SA (oxtriphylline)?

Oxtriphylline is a bronchodilator. Oxtriphylline works in several ways: it relaxes muscles in your lungs and chest to allow more air in, decreases the sensitivity of your lungs to allergens and other substances that cause inflammation, and increases the contractions of your diaphragm to draw more air into the lungs.

Oxtriphylline is used to treat the symptoms of asthma, bronchitis, and emphysema.

Oxtriphylline may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Choledyl SA (oxtriphylline)?

Call your doctor right away if you experience nausea, vomiting, insomnia, restlessness, seizures, an increased heart rate, or a headache. These could be signs of too much oxtriphylline in your blood.

Do not start or stop smoking without your doctor's knowledge. Smoking may affect your dosage.

Do not take more of this medicine than is prescribed without consulting your doctor. Seek medical attention if you are having increasing difficulty breathing.

Who should not take Choledyl SA (oxtriphylline)?

Before taking this medication, tell your doctor if you have

• a stomach ulcer;

• seizures;

• high blood pressure, a heart condition, or any type of heart disease;

• fluid in your lungs;

• a thyroid condition;

• liver disease; or

• kidney disease.

You may not be able to take oxtriphylline, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

How should I take Choledyl SA (oxtriphylline)?

Take oxtriphylline exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take your doses at the same time every day to keep a constant level of oxtriphylline in your blood.

Do not switch to another brand or a generic form of oxtriphylline without the approval of your doctor.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of a oxtriphylline overdose include nausea, vomiting, headache, insomnia, tremor (shaking hands or twitching,), restlessness, seizures, and irregular heartbeats.

What should I avoid while taking Choledyl SA (oxtriphylline)?

Do not start or stop smoking without the approval of your doctor. Smoking changes the way your body uses oxtriphylline, and you may need a dose adjustment.

Avoid changing your dose or changing the time of your daily doses.

Do not change the brand, generic form, or formulation (tablet, capsule, liquid) of oxtriphylline that you are taking without the approval of your doctor. Different brands or formulations may require different dosages.

Avoid eating excessive amounts of grilled or char-broiled foods. Doing so may also change the dose of oxtriphylline that you need.

Choledyl SA (oxtriphylline) side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• seizures;

• increased or irregular heartbeats; or

• severe nausea or vomiting.

Other, less serious side effects may occur although they are not common at appropriate doses. Continue to take oxtriphylline and talk to your doctor if you experience

• slight nausea, decreased appetite, or weight loss;

• restlessness, tremor, or insomnia; or

• headache, lightheadedness, or dizziness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Choledyl SA (oxtriphylline)?

Oxtriphylline interacts with many other drugs. Tell your doctor and pharmacist about all other medications that you are taking, including herbal remedies, vitamins, and other nonprescription items.

The following drugs may increase the levels of oxtriphylline in your blood, leading to dangerous side effects:

• alcohol;

• cimetidine (Tagamet, Tagamet HB);

• fluoroquinolone antibiotics such as enoxacin (Penetrex), lomefloxacin (Maxaquin), ciprofloxacin (Cipro), norfloxacin (Noroxin), and ofloxacin (Floxin);

• clarithromycin (Biaxin) and erythromycin (Ery-Tab, E.E.S., E-Mycin, others);

• disulfiram (Antabuse);

• estrogens (Ogen, Premarin, and many other types);

• fluvoxamine (Luvox);

• methotrexate (Folex, Rheumatrex);

• mexiletine (Mexitil) and propafenone (Rythmol);

• propranolol (Inderal);

• tacrine (Cognex);

• ticlopidine (Ticlid); and

• verapamil (Verelan, Calan, Isoptin).

The following drugs may decrease theophylline levels in your blood, leading to poor asthma control:

• aminoglutethimide (Cytadren),

• carbamazepine (Tegretol),

• isoproterenol (Isuprel),

• moricizine (Ethmozine),

• phenobarbital (Luminal, Solfoton),

• phenytoin (Dilantin),

• rifampin (Rifadin), and

• sucralfate (Carafate).

Drugs other than those listed here may also interact with oxtriphylline or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about oxtriphylline written for health professionals that you may read.

What does my medication look like?

Many different formulations of oxtriphylline are available with a prescription under the brand name Choledyl and generically. Regular-release tablets, sustained-release tablets, a syrup, and an elixir are all available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.