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Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets is used for:

Relieving congestion, sneezing, runny nose, and itchy, watery eyes due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets is an antihistamine, decongestant, and anticholinergic combination. It works by blocking histamine, a substance in the body that causes sneezing, runny nose, and watery eyes. It also relieves nasal congestion by shrinking the nasal mucous membranes, which promotes nasal drainage, and dries the chest by decreasing lung secretions.

Do NOT use Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets if:

• you are allergic to any ingredient in Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets
• you are pregnant or breast-feeding
• you are taking sodium oxybate (GHB)
• you are taking or have taken medicine for high blood pressure or depression in the last 14 days, or you have taken furazolidone within the last 5 days
• you have a history of narrow-angle glaucoma, blockage in the stomach or intestines, peptic ulcer disease, intestinal or bowel problems, difficulty urinating, inflammation of the esophagus from reflux disease, difficulty swallowing, or uncontrolled bleeding
• you have severe heart disease or severe high blood pressure

Contact your doctor or health care provider right away if any of these apply to you.

Before using Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets:

Some medical conditions may interact with Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have diabetes, an enlarged prostate, a history of bladder or kidney problems, high blood pressure, diarrhea, asthma, nerve problems, heart problems, blood clots, a hiatal hernia, an adrenal gland tumor, glaucoma, breathing problems during sleep, myasthenia gravis (muscle weakness), or an overactive thyroid

Some MEDICINES MAY INTERACT with Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Furazolidone, medicines for treating high blood pressure such as alpha-blockers (eg, prazosin, guanethidine, methyldopa), beta-blockers (eg, atenolol), diuretics (eg, furosemide, hydrochlorothiazide), or medicines for treating depression such as monoamine oxidase (MAO) inhibitors (eg, phenelzine) or tricyclic antidepressants (eg, amitriptyline)
• Alkalizers (eg, calcium or magnesium antacids), anesthetics (eg, chloroform, lidocaine), anticholinergics (eg, atropine, benztropine, dicyclomine), carbonic anhydrase inhibitors (eg, acetazolamide), ergotamine, or sodium bicarbonate because the side effects of Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may be increased
• Bromocriptine, certain stimulants (eg, doxapram, pseudoephedrine), cocaine, catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), digoxin, droxidopa, potassium chloride, or sodium oxybate because side effects may be increased by Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets:

Use Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Swallow whole. Do not break, crush, or chew before swallowing.
• Do not take Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets at the same time as antacids, certain medicines for diarrhea (eg, kaolin, pectin, attapulgite, bismuth), or ketoconazole. Take these medicines 2 or 3 hours before or after taking Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets.
• If you miss a dose of Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets.

Important safety information:

• Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may cause drowsiness, dizziness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets. Using Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets. Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• If your symptoms do not improve within 7 days or if you develop a high fever or persistent headache, check with your doctor.
• Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may interfere with certain lab test results. Be sure your doctors and laboratory personnel know that you are taking Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets.
• Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may cause dry mouth. To relieve dry mouth, suck on sugarless hard candy or ice chips, chew sugarless gum, drink water, or use a saliva substitute.
• Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may cause your eyes to become sensitive to sunlight. Wearing sunglasses may help.
• Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may reduce sweating. Do not become overheated in hot weather or during exercise or other activities because heatstroke may occur.
• Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets contains the stimulant phenylephrine. Do not take diet or appetite control medicines while you are taking Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets without checking with your doctor.
• If you have trouble sleeping, ask your doctor or pharmacist about the best time of the day to take Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets.
• Diabetes patients - Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
• Caution is advised when using Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets the ELDERLY because they may be more sensitive to its effects.
• Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets is not recommended for use in CHILDREN younger than 6 years of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Do not use Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets if you are pregnant. If you suspect that you could be pregnant, contact your doctor immediately. Do not use Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets during labor or delivery because it may cause harm to the fetus. Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets is excreted in breast milk. Do not breast-feed while taking Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets.

When used for long periods of time, Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets may not work as well. This is known as TOLERANCE. Increasing the dose will cause toxic side effects to occur. If you suddenly stop taking Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets, WITHDRAWAL symptoms, including depression, may occur.

Possible side effects of Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; clumsiness; constipation; dizziness; drowsiness; dry mouth, nose, or throat; excitability or irritability (especially in children); flushing; giddiness; headache; lack of energy; nausea; nervousness; tearing; trouble sleeping; unusual tiredness or weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty swallowing; mental or mood changes; pounding in the chest; unusual bleeding or bruising; urinary retention; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include convulsions; deep sleep or loss of consciousness; hot or cool skin; irregular heartbeat; irritability, anxiety, or panic; large pupils; numbness or tingling in the arms or legs; seizures; slowed or shallow breathing; vomiting.

Store Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C) in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Chlorpheniramine/Phenylephrine/Methscopolamine Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.