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Trade Names:
AH-chew
- Tablets 10 mg phenylephrine, 2 mg chlorpheniramine, 1.25 mg methscopolamine

Trade Names:
Dallergy
- Syrup 10 mg phenylephrine, 2 mg chlorpheniramine, 0.625 mg methscopolamine
- Tablets 10 mg phenylephrine, 4 mg chlorpheniramine, 1.25 mg methscopolamine
- Tablets 20 mg phenylephrine, 12 mg chlorpheniramine, 2.5 mg methscopolamine

Trade Names:
Dehistine
- Syrup 10 mg phenylephrine, 2 mg chlorpheniramine, 1.25 mg methscopolamine

Trade Names:
DriHist
- SR Tablets 20 mg phenylephrine, 8 mg chlorpheniramine, 2.5 mg methscopolamine

Trade Names:
Duradryl
- Syrup 10 mg phenylephrine, 2 mg chlorpheniramine, 1.25 mg methscopolamine

Trade Names:
Ex-Histine
- Syrup 10 mg phenylephrine, 2 mg chlorpheniramine, 1.25 mg methscopolamine

Trade Names:
Extendryl
- Chewable Tablets 10 mg phenylephrine, 2 mg chlorpheniramine, 1.25 mg methscopolamine
- SR Capsules 20 mg phenylephrine, 8 mg chlorpheniramine, 2.5 mg methscopolamine
- Syrup 10 mg phenylephrine, 2 mg chlorpheniramine, 1.25 mg methscopolamine

Trade Names:
Hista-Vent DA
- Tablets 20 mg phenylephrine, 8 mg chlorpheniramine, 2.5 mg methscopolamine

Trade Names:
Omnihist L.A.
- Tablets 20 mg phenylephrine, 8 mg chlorpheniramine, 2.5 mg methscopolamine

Trade Names:
Pre-Hist-D
- Tablets 20 mg phenylephrine, 8 mg chlorpheniramine, 2.5 mg methscopolamine

Mechanism of Action

Pharmacology

Competitively antagonizes histamine at H ₁ receptor sites.

Stimulates postsynaptic alpha-receptors, resulting in vasoconstriction, which reduces congestion.

Competitively inhibits action of acetylcholine at muscarinic receptors.

Indications and Usage

Temporary relief of symptoms of allergic rhinitis, vasomotor rhinitis, sinusitis, and the common cold.

Contraindications

Hypersensitivity or idiosyncratic reaction to any ingredients of product; severe hypertension; severe coronary artery disease; narrow-angle glaucoma; urinary retention; hyperthyroidism; peptic ulcer; asthma attack; MAOI therapy or for 2 wk after stopping MAOI therapy.

Dosage and Administration

PO 1 tablet/capsule every 12 h.

PO ½ tablet/capsule every 12 h.

PO 1 to 2 tablets every 4 h.

PO 1 tablet every 4 h.

PO As recommended by health care provider.

PO 1 to 2 tsp (5 to 10 mL) every 3 to 4 h.

PO ½ to 1 tsp (2.5 to 5 mL), depending on weight of child; may repeat every 4 h.

PO As recommended by health care provider.

PO 1 tablet every 12 h.

PO ½ tablet every 12 h.

General Advice

• Syrup
• Give with food or milk if GI upset occurs.
• Use dosing spoon or syringe for pediatric doses of syrup.

• Chewable tablets
• Give with food or milk if GI upset occurs.

• Extended-release formulations
• Caplets may be broken in half but should not be crushed or chewed.
• Give with food or milk if GI upset occurs.

Storage/Stability

Store at controlled room temperature. Keep syrup tightly capped and protect from freezing.

Store at controlled room temperature (69° to 77°F).

Store at controlled room temperature (69° to 77°F).

Drug Interactions

Effects may be enhanced by chlorpheniramine.

May prolong and intensify the effects of chlorpheniramine and increase the effects of phenylephrine.

Antihypertensive effects may be reduced by phenylephrine.

Laboratory Test Interactions

May interfere with diagnostic test results for skin tests using allergen extracts.

Adverse Reactions

Cardiovascular

Tachycardia; palpitations; arrhythmias; CV collapse; hypotension.

CNS

Drowsiness; dizziness.

Nervousness; insomnia; restlessness; headache; fear; anxiety; tremor; weakness; insomnia; hallucinations; convulsions; CNS depression; irritability; tenseness.

Dermatologic

Pallor.

EENT

Blurred vision; nose, throat, and mouth dryness.

GI

Gastric irritation and irritability.

Genitourinary

Urinary retention.

Dysuria; urinary retention.

Respiratory

Respiratory difficulty.

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

Safety and efficacy in children younger than 6 yr of age not established. Antihistamines may cause excitability in children.

Elderly

Patients 60 yr of age and older more likely to exhibit adverse reactions.

Special Risk Patients

Use with caution in patients with hypertension, heart disease, asthma, hyperthyroidism, increased IOP, diabetes mellitus, and prostatic hypertrophy.

Overdosage

Symptoms

Dry mouth, dilated pupils, hallucinations, severe hypertension, ventricular extrasystoles, short paroxysms of ventricular tachycardia, CNS depression, CNS stimulation, somnolence, convulsions, shock, death.

Patient Information

• Review dosing schedule for prescribed dose form (eg, syrup, chewable tablet, extended-release tablet).
• Advise caregiver to use dosing spoon or syringe when giving syrup to children.
• Caution patient that extended-release tablet can be broken in half but that dose should be swallowed whole and not crushed or chewed.
• Advise patient to take with food or milk if GI upset occurs.
• Advise patient to take last dose late in the afternoon or early evening to reduce chance of drug causing sleeplessness.
• Advise patient that if a dose is missed to take as soon as remembered unless it is nearing time for the next dose. Caution patient to not double the dose to catch up.
• Advise patient that if allergy symptoms are not controlled, not to increase the dose of medication but to inform health care provider.
• Caution patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness until tolerance is determined.
• Advise patient to avoid alcohol and other CNS depressants because of risk of excessive sedation.
• Caution patient not to take any OTC antihistamines or decongestants while taking this medication unless advised by health care provider.
• If patient is to have allergy skin testing, advise to not take the medication for at least 6 days before the skin testing.
• Instruct patient to stop taking drug and immediately report any of the following symptoms to health care provider: nervousness, dizziness, sleeplessness.