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Generic Name: chlorpheniramine and phenylephrine (klor feh NEER a meen and fen il EFF rin)
Brand Names: Chlor-Mes Jr, Dallergy-JR, Histatab Plus, Rondec, Rynatan

What is chlorpheniramine and phenylephrine?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine and phenylephrine is used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes.

Chlorpheniramine and phenylephrine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about chlorpheniramine and phenylephrine?

Do not use this medication during an asthma attack.

Contact your doctor if your symptoms do not improve or if they get worse after taking this medicine for 7 days.

What should I discuss with my healthcare provider before taking chlorpheniramine and phenylephrine?

• severe or uncontrolled high blood pressure;

• severe coronary artery disease;

• narrow angle glaucoma;

• a stomach ulcer; or

• if you are unable to urinate.

Do not use this medication during an asthma attack.

Before using this medication, tell your doctor if you are allergic to any drugs, or if you have:

• kidney disease;
• liver disease;

• diabetes;

• glaucoma;

• circulation problems;

• heart disease or high blood pressure;

• overactive thyroid;

• a seizure disorder such as epilepsy;

• asthma, emphysema or chronic bronchitis; or

• urination problems or an enlarged prostate.

If you have any of these conditions, you may not be able to use chlorpheniramine and phenylephrine, or you may need a dosage adjustment or special tests during treatment.

How should I take chlorpheniramine and phenylephrine?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the instructions on your prescription label.

The chewable tablet must be chewed before swallowing.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Contact your doctor if your symptoms do not improve or if they get worse after taking this medicine for 7 days.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Symptoms of a chlorpheniramine and phenylephrine overdose may include nausea, vomiting, diarrhea, stomach pain, problems with balance or coordination, headache, urination problems, dizziness, feeling excited or irritable, hallucinations (seeing things), metallic taste in your mouth, tremors, fever, flushed face, and seizure (convulsions).

What should I avoid while taking chlorpheniramine and phenylephrine?

Avoid using other medicines that make you sleepy (such as cold medicine, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by chlorpheniramine.

Avoid using other medicines that may cause restlessness (such as caffeine, stimulants, diet pills, and decongestants contained in over-the-counter cold medicines). They can add to the stimulant effects of phenylephrine.

Chlorpheniramine and phenylephrine side effects

• fast or uneven heart beats;

• feeling light-headed, fainting;

• seizure (convulsions);

• hallucinations (seeing things that are not there); or

• tremors.

Continue using this medication and talk with your doctor if you have any of these less serious side effects:

• heartburn, nausea, vomiting, diarrhea, loss of appetite;

• dry nose or mouth;

• drowsiness, dizziness, weakness, headache;

• dry eyes, blurred vision;

• painful or difficult urination;

• sleep problems (insomnia);

• feeling nervous or excited (especially in children).

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect chlorpheniramine and phenylephrine?

Before taking this medication, tell your doctor if you are using any of the following drugs:

• mecamylamine (Inversine);

• methyldopa (Aldomet);

• reserpine;

• a beta-blocker such as acebutolol (Sectral), atenolol (Tenormin), betaxolol (Kerlone), bisoprolol (Zebeta), carteolol (Cartrol), carvedilol (Coreg), esmolol (Brevibloc), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), penbutolol (Levatol), pindolol (Visken), propranolol (Inderal, InnoPran), sotalol (Betapace), or timolol (Blocadren);

• a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or

• antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), clomipramine (Anafranil), desipramine (Norpramin), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

If you are using any of these drugs, you may not be able to use chlorpheniramine and phenylephrine, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect chlorpheniramine and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has additional information about chlorpheniramine and phenylephrine written for health professionals that you may read.

What does my medication look like?

Many formulations of chlorpheniramine and phenylephrine are available both over-the-counter and with a prescription. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.