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Generic Name: chlorpheniramine and codeine (klor fen near A mean and ko deen)
Brand Names: Codeprex

What is chlorpheniramine and codeine?

Chlorpheniramine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body. Chlorpheniramine prevents sneezing; itchy, watery eyes and nose; and other symptoms of allergies and colds.

Codeine is a pain reliever and a cough suppressant. It suppresses an area in the brain that causes coughing.

Chlorpheniramine and codeine are used together to treat nasal congestion and coughs associated with allergies and the common cold.

Chlorpheniramine and codeine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about chlorpheniramine and codeine?

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.

What should I discuss with my healthcare provider before taking chlorpheniramine and codeine?

• an allergy to codeine, morphine, or other narcotic medications;

• kidney disease;
• liver disease;

• diabetes;

• glaucoma;

• a head injury;

• heart disease or high blood pressure;

• intestinal problems;

• Addison's disease;

• thyroid disease;

• asthma or lung disease; or

• difficulty urinating or have an enlarged prostate.

You may not be able to take chlorpheniramine and codeine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take chlorpheniramine and codeine?

Take chlorpheniramine and codeine exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of a chlorpheniramine and codeine overdose may include severe drowsiness, dizziness, headache, seizures, dry mouth, cold and clammy skin, flushing, large pupils, nausea, vomiting, difficulty or decreased breathing, blue colored skin, and unconsciousness.

What should I avoid while taking chlorpheniramine and codeine?

Chlorpheniramine and codeine side effects

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or

• confusion, hallucinations, or unusual behavior.

Other, less serious side effects may be more likely to occur. Continue to take chlorpheniramine and codeine and talk to your doctor if you experience

• dizziness, drowsiness, or sleepiness;

• restlessness or irritability;

• blurred vision;

• constipation;

• dry mouth, nausea, vomiting, or decreased appetite;

• muscle twitches;

• sweating; or

• itching.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect chlorpheniramine and codeine?

Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking chlorpheniramine and codeine without first talking to your doctor or pharmacist. Other medications may also contain chlorpheniramine, codeine, or other similar drugs. You may accidentally take too much of these medicines.

Chlorpheniramine and codeine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if chlorpheniramine and codeine is taken with any of these medications.

Drugs other than those listed here may also interact with chlorpheniramine and codeine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

• Your pharmacist has additional information about chlorpheniramine and codeine written for health professionals that you may read.

What does my medication look like?

Chlorpheniramine and codeine is available with a prescription under the brand name Codeprex. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.