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Generic Name: sparfloxacin (spar FLOX a sin)
Brand Names: Zagam, Zagam Respipac

What is Zagam (sparfloxacin)?

Sparfloxacin has been withdrawn from the U.S. market.

Sparfloxacin is an antibiotic in a class of drugs called fluoroquinolones. It fights bacteria in the body.

Sparfloxacin is used to treat various types of bacterial infections.

Sparfloxacin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Zagam (sparfloxacin)?

Sparfloxacin has been withdrawn from the U.S. market.

What should I discuss with my healthcare provider before taking Zagam (sparfloxacin)?

Before taking this medication, tell your doctor if you have

• kidney disease;

• any kind of heart disease or heart problem; or

• seizures or epilepsy.

You may not be able to take sparfloxacin, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take Zagam (sparfloxacin)?

Take sparfloxacin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Sparfloxacin may be taken with or without food.

Take sparfloxacin at evenly spaced intervals. Follow your doctor's instructions.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

The most common symptom of a sparfloxacin overdose is irregular or slow heartbeats.

What should I avoid while taking Zagam (sparfloxacin)?

Zagam (sparfloxacin) side effects

• an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

• irregular heartbeats;

• chest pain, chest discomfort, shortness of breath, or swelling of your legs or feet;

• severe dizziness;

• seizures;

• confusion or hallucinations;

• liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue); or

• muscle or joint pain.

If you experience any of the following less serious side effects, continue taking sparfloxacin and talk to your doctor:

• nausea, vomiting, diarrhea, or constipation;

• headache, lightheadedness, or drowsiness;

• ringing in the ears; or

• increased sensitivity of the skin to sunlight.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Zagam (sparfloxacin)?

• the heart medicines amiodarone (Cordarone), disopyramide (Norpace), quinidine (Cardioquin, Quinidex, Quinaglute, others), procainamide (Procan SR, Pronestyl), sotalol (Betapace), and bepridil (Vascor);

• terfenadine (Seldane, Seldane-D) or astemizole (Hismanal);

• a tricyclic antidepressant including amitriptyline (Elavil, Endep), amoxapine (Asendin), imipramine (Tofranil), nortriptyline (Pamelor), doxepin (Sinequan), and others;

• a phenothiazine including chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), mesoridazine (Serentil), thioridazine (Mellaril), and others;

• erythromycin (E-Mycin, Ery-Tab, E.E.S., others); or

• cisapride (Propulsid).

Sparfloxacin and the drugs listed above may affect the rhythm of your heartbeats. You may not be able to take sparfloxacin, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with sparfloxacin. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

• Your pharmacist has additional information about sparfloxacin written for health professionals that you may read.

What does my medication look like?

Sparfloxacin has been withdrawn from the U.S. market.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.