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Avastin Solution is used for:

Treating colon or rectal cancer that has spread to other parts of the body. It is used with other cancer medicines.

Avastin Solution is a monoclonal antibody to vascular endothelial growth factor (VEGF). It blocks the formation and growth of new blood vessels in the tumor by targeting a protein called VEGF.

Do NOT use Avastin Solution if:

• you are allergic to any ingredient in Avastin Solution
• you have a history of coughing up blood, a high blood pressure crisis, a tear or hole in the stomach or intestine, or problems with wound healing or splitting, or you have had surgery within the last 28 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Avastin Solution:

Some medical conditions may interact with Avastin Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances, including mouse or murine proteins
• if you have a history of high blood pressure, congestive heart failure, other heart problems, or blood clotting problems
• if you have kidney problems, high amounts of protein in the urine, or a wound that has not fully healed, or you are scheduled for surgery

Some MEDICINES MAY INTERACT with Avastin Solution. However, no specific interactions with Avastin Solution are known at this time. Tell your health care provider if you are taking any other medicines.

Ask your health care provider if Avastin Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Avastin Solution:

Use Avastin Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Avastin Solution is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Avastin Solution at home, a health care provider will teach you how to use it. Be sure you understand how to use Avastin Solution. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
• Do not use Avastin Solution if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
• Do not shake the medicine.
• If you miss a dose of Avastin Solution, contact your doctor immediately to establish a new dosing schedule.

Ask your health care provider any questions you may have about how to use Avastin Solution.

Important safety information:

• If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
• Tell your doctor or dentist that you take Avastin Solution before you receive any medical or dental care, emergency care, or surgery.
• Lab tests, including blood pressure measurements and tests that measure the amount of protein in your urine, may be performed while you use Avastin Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Caution is advised when using Avastin Solution in the ELDERLY; they may be more sensitive to its effects, especially the risk of blood clotting problems (eg, stroke, heart attack).
• Avastin Solution should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Avastin Solution while you are pregnant. Women should not become pregnant while using Avastin Solution or for at least 20 days after the last treatment. It is not known if Avastin Solution is excreted in breast milk. Do not breast-feed while using Avastin Solution or for a period of time after using Avastin Solution. Contact your doctor for more information.

Possible side effects of Avastin Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal walking; confusion; constipation; diarrhea; dizziness; dry mouth; dry skin; excess tearing; fainting; frequent or urgent urination; gas; hair loss; headache; indigestion; loss of appetite; muscle pain; nail disorder; nausea; pain; pain, swelling, or redness at the injection site; skin discoloration; skin irritation; skin lesion; sores or ulcers on the mouth or lips; stomach pain; taste change; tiredness; upper respiratory tract infection; voice change; vomiting; weakness; weight loss.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abdominal pain with constipation and vomiting; black, tarry stools; blurred vision or other vision changes; calf pain or tenderness; cough; chest pain; confusion; coughing up or vomiting of blood; fever; loss of coordination; nasal pain; nosebleed; numbness of an arm or leg; numbness or loss of feeling; one-sided weakness; peeling of skin; severe, pounding, or persistent headache; severe stomach pain; shortness of breath; sluggishness; speech changes; sudden severe dizziness, vomiting, or fainting; swelling, discoloration, or pain in the legs; unusual bruising or bleeding; unusual weight gain; vision loss; wounds that do not heal.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Store Avastin Solution in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C) before mixing. Protect from light. Do not freeze. After mixing, the medicine may be stored in the refrigerator between 36 and 46 degrees F (2 and 8 degrees C) for up to 8 hours. Discard any unused medicine immediately. Keep Avastin Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Avastin Solution, please talk with your doctor, pharmacist, or other health care provider.
• Avastin Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Avastin Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.