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Perphenazine is used for:

Treating schizophrenia. It may also be used to treat severe nausea and vomiting. It may also be used for other conditions as determined by your doctor.

Perphenazine is an antipsychotic. It works by blocking dopamine receptors in the brain.

Do NOT use Perphenazine if:

• you are allergic to any ingredient in Perphenazine
• you have certain types of brain damage
• you have blood disorders, liver damage, or decreased bone marrow function
• you are taking astemizole, cisapride, terfenadine, or tramadol

Contact your doctor or health care provider right away if any of these apply to you.

Before using Perphenazine :

Some medical conditions may interact with Perphenazine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of seizures, breast cancer, asthma, trouble urinating, lung problems (eg, emphysema), alcohol abuse, or depression
• if you have a lung infection, heart or blood disease, Reye syndrome, Parkinson disease, glaucoma, high or low blood pressure, or prostate problems

Some MEDICINES MAY INTERACT with Perphenazine . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticholinergics (eg, benztropine), antihistamines (eg, diphenhydramine), barbiturates (eg, phenobarbital), opiates (eg, codeine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Perphenazine 's side effects
• Astemizole, cisapride, haloperidol, ketolide antibiotics (eg, telithromycin), macrolide antibiotics (eg, erythromycin), pimozide, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), terfenadine, or tramadol because the risk of severe heart, nervous system, or muscle problems or seizures may be increased
• Guanethidine, levodopa, or pergolide because their effectiveness may be decreased by Perphenazine

This may not be a complete list of all interactions that may occur. Ask your health care provider if Perphenazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Perphenazine :

Use Perphenazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Perphenazine by mouth with or without food.
• If you miss a dose of Perphenazine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Perphenazine .

Important safety information:

• Perphenazine may cause drowsiness, dizziness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Perphenazine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Perphenazine ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Perphenazine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Perphenazine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Perphenazine . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Do not become overheated in hot weather or while you are being active; heatstroke may occur.
• Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Perphenazine . Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
• Some patients who take Perphenazine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Perphenazine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Perphenazine .
• Tell your doctor or dentist that you take Perphenazine before you receive any medical or dental care, emergency care, or surgery.
• Lab tests, including liver and kidney function and complete blood cell counts, may be performed while you use Perphenazine . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Perphenazine with caution in the ELDERLY; they may be more sensitive to its effects.
• Perphenazine should not be used in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: It is not known if Perphenazine can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Perphenazine while you are pregnant. Perphenazine is found in breast milk. If you are or will be breast-feeding while you use Perphenazine , check with your doctor. Discuss any possible risks to your baby

If you stop taking Perphenazine suddenly, you may have WITHDRAWAL symptoms. These may include dizziness, nausea, shakiness, upset stomach, and vomiting.

Possible side effects of Perphenazine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Appetite loss; blurred vision; confusion; constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; nasal congestion; nausea; sleeplessness; tired feeling; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in breasts; changes in menstrual period; changes in vision or other vision problems; chest pain; difficulty speaking; difficulty swallowing; fainting; fast, slow, or irregular heartbeat; fever; inability to move eyes; inability to urinate; involuntary movements of the tongue, face, mouth, or jaw; lip smacking or puckering; mask-like face; mental confusion; muscle spasms of face, neck, or back; numbness of the arms and legs; prolonged or painful erection; puffing of cheeks; restlessness; seizures; severe stomach pain; shuffling walk or stiff arms or legs; sore throat; tension in leg; tightness in the throat or jaw; tremors of hands; twitching or twisting movements; unusual or excessive sweating; weakness of arms or legs; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; fast or irregular heartbeat; muscle spasms; restlessness; seizures; tremors; twitching.

Store Perphenazine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Perphenazine out of the reach of children and away from pets.

General information:

• If you have any questions about Perphenazine , please talk with your doctor, pharmacist, or other health care provider.
• Perphenazine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Perphenazine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.