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Nicardipine is used for:

Short-term treatment of high blood pressure in patients who cannot take the oral form of Nicardipine . It may also be used for other conditions as determined by your doctor.

Nicardipine is a calcium channel blocker. It works by relaxing blood vessels, which helps to lower blood pressure.

Do NOT use Nicardipine if:

• you are allergic to any ingredient in Nicardipine
• you are breast-feeding
• you have advanced narrowing of your aorta (stenosis)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Nicardipine :

Some medical conditions may interact with Nicardipine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant or planning to become pregnant
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have angina (chest pain), congestive heart failure or other heart problems, liver or kidney problems, low blood pressure, or lung congestion associated with heart attack, or have had a stroke
• you are having beta-blocker withdrawal

Some MEDICINES MAY INTERACT with Nicardipine . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Cyclosporine or digoxin because actions and side effects may be increased by Nicardipine
• Cimetidine because the side effects of Nicardipine may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nicardipine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nicardipine :

Use Nicardipine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Nicardipine is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Nicardipine at home, carefully follow the injection procedures taught to you by your health care provider.
• If Nicardipine contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
• Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
• Do not eat grapefruit or drink grapefruit juice while using Nicardipine unless your doctor directs you otherwise.
• If you miss a dose of Nicardipine , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Nicardipine .

Important safety information:

• Nicardipine may cause dizziness or fainting. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Nicardipine . Using Nicardipine alone, with other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Patients being treated for high blood pressure often feel tired or run down for a few weeks after beginning therapy. Continue taking your medicine even though you may not feel quite "normal." Contact your doctor or pharmacist about any new symptoms.
• Maximum lowering of blood pressure occurs approximately 1 to 2 hours after taking the medicine. Blood pressure should be taken 1 to 2 hours after the medicine has been taken.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Nicardipine .
• Additional monitoring of your dose or condition may be necessary if you are using intravenous (IV) calcium.
• LAB TESTS, including blood pressure, electrocardiogram (ECG) readings, and monitoring of heart rate, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Nicardipine during pregnancy. It is unknown if Nicardipine is excreted in breast milk. Do not breast-feed while taking Nicardipine .

If you suddenly stop taking Nicardipine , you may experience WITHDRAWAL symptoms including increased chest pain (angina) and more frequent chest pain.

Possible side effects of Nicardipine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; feeling of warmth (flushing); feet swelling; headache; nausea; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; fast or irregular heartbeat; increased chest pain; pounding in the chest; shortness of breath; swelling of the ankles or hands.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include confusion; drowsiness; flushing; slowed heart rate; slurred speech; weakness.

Nicardipine is usually handled and stored by a health care provider. If you are using Nicardipine at home, store Nicardipine as directed by your pharmacist or health care provider. Keep Nicardipine out of the reach of children and away from pets.

General information:

• If you have any questions about Nicardipine , please talk with your doctor, pharmacist, or other health care provider.
• Nicardipine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Nicardipine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.