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Methylin Solution is used for:

Treating attention deficit disorder (ADD). It is also used to treat uncontrollable periods of daytime sleep (narcolepsy). It may also be used for other conditions as determined by your doctor.

Methylin Solution is a central nervous system stimulant. Exactly how it works is not known.

Do NOT use Methylin Solution if:

• you are allergic to any ingredient in Methylin Solution
• you have severe anxiety, agitation, or tension
• you have glaucoma
• you have motor tics (involuntary movements), Tourette syndrome, or a family history of Tourette syndrome
• you have serious heart problems (eg, heart defect, irregular heartbeat)
• you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) or have taken an MAOI within the past 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Methylin Solution:

Some medical conditions may interact with Methylin Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of high blood pressure, heart problems (eg, heart failure, fast or irregular heartbeat), or recent heart attack, or if a family member has a history of irregular heartbeat or sudden death
• if you have a history of seizures or abnormal electroencephalograms (EEGs)
• if you have a history of overactive thyroid, chronic fatigue, cystic fibrosis, or stomach or bowel problems (eg, blockage, inflammation, narrowing)
• if you have a history of mood or mental problems (eg, agitation, anxiety, bipolar disorder, depression, psychosis, tension), abnormal thoughts, hallucinations, suicidal thoughts or attempts, or alcohol or other substance abuse or dependence, or if a family member has a history of any of these problems

Some MEDICINES MAY INTERACT with Methylin Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

• MAOIs (eg, phenelzine) because severe high blood pressure may occur
• Clonidine because serious side effects may occur
• Pressor agents (eg, norepinephrine) because the risk of high blood pressure may be increased
• Anticoagulants (eg, warfarin), certain anticonvulsants (eg, phenobarbital, phenytoin, primidone), phenylbutazone, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or tricyclic antidepressants (eg, imipramine) because the risk of their side effects may be increased by Methylin Solution
• Guanethidine or other medicines for high blood pressure because their effectiveness may be decreased by Methylin Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Methylin Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Methylin Solution:

Use Methylin Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Methylin Solution comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Methylin Solution refilled.
• Take Methylin Solution by mouth 30 to 45 minutes before eating unless your doctor tells you otherwise.
• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
• You may have trouble sleeping while taking Methylin Solution. If this occurs, taking your last dose before 6 pm may help. Check with your doctor before you change the way that you take Methylin Solution. If trouble sleeping continues, talk with your doctor.
• If you miss a dose of Methylin Solution, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Methylin Solution.

Important safety information:

• Methylin Solution may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Methylin Solution with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do NOT take more than the recommended dose without checking with your doctor.
• If your symptoms do not get better within 1 month or if they get worse, check with your doctor.
• Serious effects, including heart attack, stroke, and sudden death, have occurred with the use of stimulant medicines in patients with heart defects or other serious heart problems. If you have a heart defect or other serious problem, talk with your doctor about other therapies to treat your condition.
• Lab tests, including blood pressure, heart function, complete blood cell counts, and platelet counts, may be performed while you use Methylin Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Methylin Solution may affect growth rate and weight gain in CHILDREN and teenagers in some cases. They may need regular growth and weight checks while they take Methylin Solution.
• Caution is advised when using Methylin Solution in CHILDREN; they may be more sensitive to its effects, especially loss of appetite, stomach pain, weight loss, trouble sleeping, and fast heartbeat.
• Methylin Solution should not be used in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Methylin Solution while you are pregnant. It is not known if Methylin Solution is found in breast milk. If you are or will be breast-feeding while you use Methylin Solution, check with your doctor. Discuss any possible risks to your baby.

When used for long periods of time or at high doses, Methylin Solution may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Methylin Solution stops working well. Do not take more than prescribed.

Some people who use Methylin Solution for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. Do not suddenly stop taking Methylin Solution. If you do, you may have WITHDRAWAL symptoms. These may include depression or other mental problems. If you need to stop Methylin Solution, your doctor will lower your dose over time.

Possible side effects of Methylin Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; headache; loss of appetite; nausea; nervousness; stomach pain; trouble sleeping.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; joint pain; purple or brownish red spots on the skin); behavior changes (eg, aggression, hostility); blurred vision or other vision problems; chest pain; confusion; dark urine; fainting; fast or irregular heartbeat; fever, chills, or sore throat; hallucinations; mental or mood changes (eg, agitation, anxiety, depression, irritability, persistent crying, unusual sadness); seizures; severe or persistent dizziness or headache; suicidal thoughts or attempts; uncontrolled speech or muscle movements; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include confusion; dilated pupils; fast or irregular heartbeat; fever; flushing; hallucinations; loss of consciousness; muscle twitching; seizures; severe or persistent headache; tremors; unusual sweating; vomiting.

Store Methylin Solution between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Methylin Solution out of the reach of children and away from pets.

General information:

• If you have any questions about Methylin Solution, please talk with your doctor, pharmacist, or other health care provider.
• Methylin Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Methylin Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.