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Memantine is used for:

Treating moderate to severe Alzheimer-type dementia. It may also be used for other conditions as determined by your doctor.

Memantine is a NMDA-receptor antagonist. It works by blocking excess activity of a substance in the brain called glutamate, which may reduce the symptoms associated with Alzheimer disease. Memantine is not a cure for Alzheimer disease.

Do NOT use Memantine if:

• you are allergic to any ingredient in Memantine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Memantine :

Some medical conditions may interact with Memantine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have kidney problems or a condition that raises your urine pH balance (eg, urinary tract infection)

Some MEDICINES MAY INTERACT with Memantine . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Amantadine, carbonic anhydrase inhibitors (eg, acetazolamide), dextromethorphan, ketamine, or sodium bicarbonate because they may increase the risk of Memantine 's effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Memantine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Memantine :

Use Memantine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Memantine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Use Memantine as directed on the packaging unless otherwise directed by your doctor.
• If you miss a dose of Memantine , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Memantine .

Important safety information:

• Memantine may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Memantine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Memantine while you are pregnant. It is not known if Memantine is found in breast milk. If you are or will be breast-feeding while you use Memantine , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Memantine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; headache; pain.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in behavior, such as aggressiveness, depression, or anxiety; chest pain or tightness; fainting; hallucinations; one-sided weakness; severe tiredness; speech changes; sudden severe headache; vision changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include confusion; loss of consciousness; mental or mood changes; restlessness; seeing things that are not there (hallucinations); severe drowsiness.

Store Memantine at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Memantine out of the reach of children and away from pets.

General information:

• If you have any questions about Memantine , please talk with your doctor, pharmacist, or other health care provider.
• Memantine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Memantine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.