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Generic Name: mitotane (MY toe tain)
Brand Names: Lysodren

What is Lysodren (mitotane)?

Mitotane is a cancer (antineoplastic) medication. Mitotane interferes with the growth of cancer cells and slows their growth and spread in the body.

Mitotane is used to treat cancer of the adrenal gland (adrenal cortical carcinoma).

Mitotane may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Lysodren (mitotane)?

Mitotane should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Mitotane can lower the ability of the body to respond to injury, illness, and other forms of stress. Notify your doctor if you sustain an injury, become ill, or are under a significant amount of stress so that treatment can be started if necessary.

What should I discuss with my healthcare provider before taking Lysodren (mitotane)?

Before taking mitotane, tell your doctor if you:

• have any other serious illness or injury; or

• liver disease.

You may not be able to take mitotane, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take Lysodren (mitotane)?

Take this medication exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Mitotane should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Your doctor will determine the correct amount and frequency of treatment with mitotane depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with mitotane to monitor progress and side effects.

What happens if I miss a dose?

Contact your doctor if you miss a dose of mitotane.

What happens if I overdose?

Symptoms of a mitotane overdose may be similar to side effects caused by the medication, although often more severe.

What should I avoid while taking Lysodren (mitotane)?

Mitotane can lower the ability of the body to respond to injury, illness, and other forms of stress. Notify your doctor if you sustain an injury, become ill, or are under a significant amount of stress so that treatment can be started if necessary.

Lysodren (mitotane) side effects

• an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);

• fever;

• blurred or double vision; or

• blood in the urine.

Other less serious side effects may be more likely to occur. Talk to your doctor if you experience

• dizziness;

• generalized aching ;

• fatigue or drowsiness;

• skin rash;

• nausea, vomiting, diarrhea; or

• loss of appetite;

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Lysodren (mitotane)?

Before taking mitotane, tell your doctor if you are taking

• warfarin (Coumadin) or another blood thinner; or

• spironolactone (Aldactone).

You may require a dosage adjustment or special monitoring during treatment if you are taking one of these medicines.

Drugs other than those listed here may also interact with mitotane. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with mitotane.

Where can I get more information?

• Your pharmacist has additional information about mitotane written for health professionals that you may read.

What does my medication look like?

Mitotane is available with a prescription under the brand name Lysodren. Other brand or generic formulations may also be available. Ask your doctor or pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.