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Generic Name: lomustine (LOW muh steen)
Brand Names: Ceenu

What is lomustine?

Lomustine is a cancer (antineoplastic) medication. Lomustine interferes with the growth of cancer cells and slows their growth and spread in the body.

Lomustine is used to treat cancerous brain tumors and the blood cancer Hodgkin's disease.

Lomustine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about lomustine?

Lomustine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of lomustine including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection such as fever; chills, or sore throat); lung problems (shortness of breath, dry cough); swelling of the feet or lower legs; mental confusion; liver problems (yellowing of the skin or eyes); and others. Talk to your doctor about the possible side effects from treatment with lomustine.

In some cases, second cancers have been reported to occur during and following treatment with lomustine. Also, lomustine has been associated with the lung disorder pulmonary fibrosis. Talk to your doctor about the risks and benefits of this medication.

What should I discuss with my healthcare provider before taking lomustine?

Before taking lomustine, tell your doctor if you have

• had recent vaccinations;

• liver disease;

• have bone marrow problems;

• have a history of lung or breathing problems; or

• kidney disease.

You may not be able to take lomustine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take lomustine?

Take lomustine exactly as directed by your doctor. If you do not understand these instructions, ask your doctor, nurse or pharmacist to explain them to you.

Lomustine is usually given as a single dose which may be repeated in six or more weeks following recovery of the blood. To get the correct dose, you may be given a combination of two or more different types and colors of capsules.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with lomustine to monitor progress and side effects.

What happens if I miss a dose?

Contact your doctor if you miss a dose of lomustine.

What happens if I overdose?

Symptoms of a lomustine overdose tend to be similar to side effects caused by the medication, although often more severe.

What should I avoid while taking lomustine?

Lomustine can lower the activity of your immune system making you susceptible to infections. Avoid contact with people who have colds, the flu, or other contagious illnesses and do not receive vaccines that contain live strains of a virus (e.g., live oral polio vaccine) during treatment with lomustine. In addition, avoid contact with individuals who have recently been vaccinated with a live vaccine. There is a chance that the virus can be passed on to you.

Lomustine side effects

• an allergic reaction (shortness of breath; closing of your throat; difficulty breathing; swelling of your lips, face, or tongue; or hives);

• decreased bone marrow function and blood problems (extreme fatigue; unusual bruising or bleeding; black, bloody or tarry stools; or fever, chills, sore throat, or signs of infection);

• shortness of breath or dry cough;

• swelling of feet or lower legs;

• little or no urine production;

• yellowing of the eyes or skin; or

• mental confusion.

Other less serious side effects may be more likely to occur. Talk to your doctor if you experience

• loss of appetite, nausea, or vomiting;

• mouth sores;

• temporary hair loss;

• visual changes;

• disorientation;

• fatigue or tiredness;

• decreased coordination; or

• speech disturbances.

In some cases, second cancers have been reported to occur during and following treatment with lomustine. Also, lomustine has been associated with the lung disorder pulmonary fibrosis. Talk to your doctor about the risks and benefits of this medication.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect lomustine?

Other drugs may interact with lomustine. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with lomustine.

Where can I get more information?

• Your pharmacist has additional information about lomustine written for health professionals that you may read.

What does my medication look like?

Lomustine is available with a prescription under the brand name CeeNU. Other brand or generic formulations may also be available. Ask your doctor or pharmacist any questions you have about this medication, especially if it is new to you.

• CeeNU 10 mg-white capsules

• CeeNU 40 mg-white and green capsules

• CeeNU 100 mg-green capsules

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.