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Generic name: Inderal (Propranolol hydrochloride), Hydrochlorothiazide
Brand names: Inderide LA, Inderide

Why is Inderide prescribed?

Inderide is used in the treatment of high blood pressure. It combines a beta blocker (Inderal) with a thiazide diuretic (hydrochlorothiazide). Beta blockers decrease the force and rate of heart contractions, thus lowering blood pressure. Diuretics help your body produce and eliminate more urine, which also helps lower blood pressure.

Most important fact about Inderide

You must take Inderide regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Inderide; and you must continue taking it even if you are feeling well. Inderide does not cure high blood pressure; it merely keeps it under control.

How should you take Inderide?

Take Inderide exactly as prescribed, even if your symptoms have disappeared.

Try not to miss any doses. If Inderide is not taken regularly, your condition may worsen.

--If you miss a dose...

Take it as soon as you remember. If the next dose is within 8 hours, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time.

--Storage instructions...

Store at room temperature in a tightly closed container, protected from moisture, freezing, and excessive heat.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Inderide.

• Side effects may include:
  Allergic reactions, blood disorders, congestive heart failure, inflammation of the pancreas, depression, light-headedness, low blood pressure, nausea, slow heartbeat, vomiting

Why should Inderide not be prescribed?

If you have inadequate blood supply to the circulatory system (cardiogenic shock), certain types of irregular heartbeat, slow heartbeat, bronchial asthma, or congestive heart failure, you should not take Inderide.

Do not take Inderide if you are unable to urinate or if you are sensitive to or have ever had an allergic reaction to any of its ingredients or to sulfa drugs.

Special warnings about Inderide

Inderide should not be stopped suddenly. This can cause chest pain and even heart attack. Dosage should be gradually reduced.

Diuretics can cause your body to lose too much potassium. Signs of an excessively low potassium level include muscle weakness and rapid or irregular heartbeat. To boost your potassium level, your doctor may recommend eating potassium-rich foods or taking a potassium supplement.

If you suffer from asthma, seasonal allergies or other bronchial conditions, or kidney or liver disease, your doctor will prescribe Inderide with caution.

This medication may mask the symptoms of low blood sugar or alter blood sugar levels. If you are diabetic, discuss this with your doctor.

If you have a history of allergies or bronchial asthma, you are more likely to have an allergic reaction to Inderide.

Inderide may interfere with the screening test for glaucoma (excessive pressure in the eyes) and pressure within the eyes may increase when the medication is stopped.

Notify your doctor or dentist that you are taking Inderide if you have a medical emergency, and before you have surgery or dental treatment.

Possible food and drug interactions when taking Inderide

If Inderide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Inderide with the following:

ACTH (adrenocorticotropic hormone)
Alcohol
Aluminum hydroxide gel (Amphojel)
Antipyrine (Auralgan)
Calcium-blocking blood pressure drugs such as Calan, Cardizem, and Procardia XL
Certain blood pressure medications such as Diupres and Ser-Ap-Es
Chlorpromazine (Thorazine)
Cimetidine (Tagamet)
Corticosteroids such as prednisone
Digitalis (Lanoxin)
Epinephrine (EpiPen)
Haloperidol (Haldol)
Insulin
Lidocaine (Xylocaine)
Nonsteroidal anti-inflammatory drugs such as Motrin
Norepinephrine (Levophed)
Oral diabetes drugs such as Micronase
Phenobarbitone
Phenytoin (Dilantin)
Rifampin (Rifadin)
Theophylline (Theo-Dur)
Thyroid medications such as Synthroid

Special information if you are pregnant or breastfeeding

The effects of Inderide during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Inderide appears in breast milk and could affect a nursing infant. If Inderide is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

Recommended dosage

ADULTS

Your doctor will tailor your dosage according to your response to Inderide's main ingredients.

The usual dose is one Inderide tablet, 2 times per day.

Your doctor may use Inderide in combination with other high blood pressure drugs to achieve the desired effect.

This drug is also available in a sustained-release formulation, called Inderide LA, for once-a-day dosing.

CHILDREN

The safety and effectiveness of Inderide in children have not been established.

OLDER ADULTS

Your doctor will adjust your dosage with extra caution.

Overdosage

Any medication taken in excess can have severe consequences. If you suspect an overdose, seek medical attention immediately.

• Symptoms of Inderide overdose may include:
  Coma, extremely slow heartbeat heart failure, increased urination, irritation and overactivity of the stomach and intestines, low blood pressure, sluggishness, stupor, wheezing