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Generic Name: hydrochlorothiazide and captopril (hye droe klor oh THYE a zide and KAP toe prill)
Brand Names: Capozide 25/15, Capozide 25/25, Capozide 50/15, Capozide 50/25

What is hydrochlorothiazide and captopril?

Hydrochlorothiazide is a thiazide diuretic (water pill). It helps to lower your blood pressure and decrease edema (swelling) by increasing the amount of water and salt you lose in your urine.

Captopril is in a class of drugs called angiotensin-converting-enzyme inhibitors (ACE inhibitors). Captopril is used to lower blood pressure and to relieve the symptoms of congestive heart failure, including shortness of breath and swelling of the legs.

Hydrochlorothiazide and captopril is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and captopril may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about hydrochlorothiazide and captopril?

Captopril may increase the risk of dangerous allergic reactions. Before taking hydrochlorothiazide and captopril, tell your doctor if you have ever had an allergic reaction that involved swelling of your lips, face, tongue, or throat or difficulty breathing. Seek emergency medical attention if you develop any of these symptoms while taking hydrochlorothiazide and captopril.

Who should not take hydrochlorothiazide and captopril?

Captopril may increase the risk of dangerous allergic reactions. Before taking hydrochlorothiazide and captopril, tell your doctor if you have ever had an allergic reaction that involved swelling of your lips, face, tongue, or throat or difficulty breathing. Seek emergency medical attention if you develop any of these symptoms while taking hydrochlorothiazide and captopril.

Before taking hydrochlorothiazide and captopril, tell your doctor if you

• have diabetes,

• have gout,

• have a collagen vascular disease such as systemic lupus erythematosus or scleroderma,

• have pancreatitis;

• have kidney disease,
• have liver disease,

• have a blood or bone marrow disease,

• have any type of heart disease or have had a stroke,

• are taking salt substitutes, potassium supplements (e.g., K-Dur, Klor-Con), or potassium-sparing diuretics such as amiloride (Midamor), triamterene (Dyrenium, Dyazide, Maxzide), or spironolactone (Aldactone); or

• are on a salt-restricted diet or have high levels of potassium in your blood.

You may not be able to take hydrochlorothiazide and captopril, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

How should I take hydrochlorothiazide and captopril?

Take hydrochlorothiazide and captopril exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

To reduce nighttime urination, take hydrochlorothiazide and captopril before 6 p.m. and preferably in the morning.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of a hydrochlorothiazide and captopril overdose might include increased urination, nausea, vomiting, diarrhea, dizziness, fainting, weakness, fatigue, and unconsciousness.

What should I avoid while taking hydrochlorothiazide and captopril?

Avoid a diet high in salt. Too much salt may cause your body to retain water and may decrease the effects of hydrochlorothiazide. Ask your doctor or nurse about low-salt diet alternatives.

Do not use salt substitutes or potassium supplements while taking captopril and hydrochlorothiazide without first talking to your doctor. These products could cause potassium levels in your blood to become dangerously high.

Heavy sweating, vomiting, diarrhea, or other causes of fluid loss may lead to very low blood pressure, dizziness, and fainting during therapy with hydrochlorothiazide and captopril. Maintain proper fluid intake to prevent dehydration and related adverse effects.

Hydrochlorothiazide and captopril side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• fainting spells;

• unusual fatigue or abnormal bleeding or bruising;

• yellow skin or eyes;

• confusion;

• fever, chills, or a sore throat;

• little or no urine;

• irregular heartbeats; or

• increased swelling.

Other, less serious side effects may be more likely to occur. Continue to take hydrochlorothiazide and captopril and talk to your doctor if you experience

• dizziness or lightheadedness;

• headache;

• fatigue;

• tingling or numbness in your arms, legs, hands, or feet;

• excessive urination;

• muscle weakness or cramps;

• increased hunger or thirst;

• nausea, diarrhea, constipation, decreased appetite, or changes in taste;

• sensitivity to sunlight;

• dry, tickling cough;

• anxiety or depression; or

• itching, rash, or increased sweating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect hydrochlorothiazide and captopril?

Before taking hydrochlorothiazide and captopril, tell your doctor if you are taking any of the following drugs:

• a potassium supplement such as K-Dur, Klor-Con, and others;

• a salt substitute that contains potassium;

• another diuretic (water pill) especially triamterene (Dyrenium, Maxzide, Dyazide), spironolactone (Aldactone), or amiloride (Midamor);

• cholestyramine (Questran) or colestipol (Colestid);

• a nonsteroidal anti-inflammatory drug (NSAID) such as ibuprofen (Motrin, Advil), ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Anaprox, Aleve), diclofenac (Cataflam, Voltaren), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), mefenamic acid (Ponstel), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin);

• an oral diabetes medication such as glipizide (Glucotrol), glyburide (Micronase, Glynase, Diabeta), chlorpropamide (Diabinese), tolazamide (Tolinase), tolbutamide (Orinase), and others;

• tetracycline (Sumycin, others);

• lithium (Lithane, Lithobid, Eskalith, others);

• a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor XR, Tiazac), nifedipine (Adalat, Procardia), verapamil (Calan, Verelan, Isoptin), and others;

• doxazosin (Cardura), prazosin (Minipress), or terazosin (Hytrin);

• reserpine, guanadrel (Hylorel), or guanethidine (Ismelin);

• a nitrate such as nitroglycerin (Nitrostat, Transderm-Nitro, Nitro-Dur, Nitro-Bid, Minitran, others), isosorbide mononitrate (Imdur, ISMO), or isosorbide dinitrate (Isordil, Sorbitrate);

• a pain reliever such as codeine, morphine (MS Contin, MSIR, Roxanol, others), propoxyphene (Darvocet, Darvon, Wygesic), oxycodone (Percocet, Percodan), meperidine (Demerol), and others;

• a barbiturate such as phenobarbital (Luminal, Solfoton), amobarbital (Amytal), secobarbital (Seconal), and butabarbital (Butisol); or

• a steroid medicine such as cortisone (Cortone), dexamethasone (Decadron, Hexadrol), betamethasone (Celestone), hydrocortisone (Cortef, Hydrocortone), prednisone (Orasone, Deltasone), prednisolone (Delta Cortef, Prelone), methylprednisolone (Medrol), and others.

You may not be able to take hydrochlorothiazide and captopril, or you may require a dosage adjustment or special monitoring during your treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with hydrochlorothiazide and captopril or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has additional information about hydrochlorothiazide and captopril written for health professionals that you may read.

What does my medication look like?

Hydrochlorothiazide and captopril is available with a prescription under the brand name Capozide. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

Captopril/hydrochlorothiazide strengths are as follows:

• Capozide 25/15 (25 mg/15 mg)--white-and-orange mottled tablets

• Capozide 25/25 (25 mg/25 mg)--peach-colored mottled tablets

• Capozide 50/15 (50 mg/15 mg)--white-and-orange mottled tablets

• Capozide 50/25 (50 mg/25 mg)--peach-colored mottled tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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