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Generic Name: frovatriptan (FRO va trip tin)
Brand Names: Frova

What is frovatriptan?

Frovatriptan is a headache medicine. It is believed to work by narrowing the blood vessels around the brain. Frovatriptan also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Frovatriptan is used to treat migraine headaches.

Frovatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Frovatriptan may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about frovatriptan?

Before using frovatriptan, tell your doctor if you have coronary artery disease, or risk factors for coronary artery disease (such as diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

Frovatriptan will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

After taking a frovatriptan tablet, you must wait two (2) hours before taking a second tablet. Do not take more than three (3) frovatriptan tablets in 24 hours.

What should I discuss with my healthcare provider before using frovatriptan?

• a history of heart disease, angina (chest pain), blood circulation problems, or history of a heart attack or stroke;

• severe liver disease;

• ischemic bowel disease;

• severe or uncontrolled high blood pressure; or

• a headache that is not like other headaches you have had.

• almotriptan (Axert), eletriptan (Relpax), naratriptan (Frova), sumatriptan (Imitrex), rizatriptan (Maxalt), or zolmitriptan (Zomig); or

• ergot medicine such as methysergide (Sansert), ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), methylergonovine (Methergine).

Before using frovatriptan, tell your doctor if you have:

• high blood pressure;

• liver disease; or

• coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

If you have any of these conditions, you may not be able to use frovatriptan, or you may need a dosage adjustment or special tests during treatment.

How should I use frovatriptan?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Take frovatriptan as soon as you notice headache symptoms, or after an attack has already begun.

Your doctor may want to give your first dose of this medicine in a hospital or clinic setting to see if you have any serious side effects.

After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet two (2) hours after the first. Do not take more than three (3) frovatriptan tablets in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets.

Contact your doctor if you have more than four headaches in one month (30 days).

What happens if I miss a dose?

Since frovatriptan is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using frovatriptan.

After taking a frovatriptan tablet, you must wait two (2) hours before taking a second tablet. Do not take more than three (3) frovatriptan tablets in 24 hours.

What happens if I overdose?

Symptoms of a frovatriptan overdose may include severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure (convulsions), neck stiffness, tiredness, lack of coordination, feeling light-headed, or fainting.

What should I avoid while using frovatriptan?

Frovatriptan side effects

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

• sudden numbness or weakness, especially on one side of the body;

• sudden headache, confusion, problems with vision, speech, or balance;

• fast heart rate, agitation, muscle stiffness, hallucinations, lack of coordination, with nausea, vomiting, or diarrhea;

• sudden and severe stomach pain and bloody diarrhea; or

• numbness or tingling and a pale or blue-colored appearance in your fingers or toes.

Continue using frovatriptan and talk with your doctor if you have any of these less serious side effects:

• dizziness, tired feeling;

• mild headache (not a migraine);

• dry mouth, stomach pain;

• feeling too warm or too cold;

• warmth or redness under your skin;

• joint or bone pain;

• pressure or heavy feeling in any part of your body;

• feeling of pain or pressure in your neck and throat;

• anxiety, sleep problems (insomnia);

• runny or stuffy nose; or

• sweating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect frovatriptan?

Before using frovatriptan, tell your doctor if you are using any of the following drugs:

• propranolol (Inderal, InnoPran);

• an antidepressant such as citalopram (Celexa), duloxetine (Cymbalta), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), or venlafaxine (Effexor);

• another migraine medicine such as almotriptan (Axert), eletriptan (Relpax), naratriptan (Amerge), sumatriptan (Imitrex), rizatriptan (Maxalt), or zolmitriptan (Zomig).

If you are using any of these drugs, you may not be able to use frovatriptan, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect frovatriptan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has more information about frovatriptan written for health professionals that you may read.

What does my medication look like?

Frovatriptan is available with a prescription under the brand name Frova. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Frova 2.5 mg--white, round, film-coated tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.