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Fluconazole Single-Dose Tablets is used for:

Treating vaginal yeast infections. It may also be used to treat mouth and throat infections and certain types of meningitis. It is also used to prevent mouth and throat infections in patients undergoing a bone marrow transplant. It may also be used for other conditions as determined by your doctor.

Fluconazole Single-Dose Tablets is an azole antifungal. It works by killing sensitive fungi by interfering with the formation of the fungal cell membrane and weakening it.

Do NOT use Fluconazole Single-Dose Tablets if:

• you are allergic to any ingredient in Fluconazole Single-Dose Tablets
• you are taking astemizole, an aldosterone blocker (eg, eplereone), cisapride, an ergot alkaloid (eg, ergotamine), erythromycin, pimozide, a serotonin (5-HT₁) receptor agonist (eg, eletriptan), or terfenadine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fluconazole Single-Dose Tablets:

Some medical conditions may interact with Fluconazole Single-Dose Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines or other substances
• if you have a weakened immune system; kidney or liver disease; HIV infection; diabetes; or heart problems, including irregular heartbeat

Some MEDICINES MAY INTERACT with Fluconazole Single-Dose Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aldosterone blockers (eg, eplerenone), amiodarone, astemizole, cisapride, pimozide, serotonin receptor agonists (eg, eletriptan), macrolide antibiotics (eg, erythromycin), quinolines (eg, ciprofloxacin), or terfenadine because the risk of severe irregular heartbeat (eg, QT prolongation) may be increased
• Rifabutin because the risk of certain eye problems (eg, uveitis) may be increased
• Macrolide immunosuppressants (eg, tacrolimus) because the risk of kidney problems may be increased
• Rifampin or proton pump inhibitors (eg, omeprazole) because they may decrease Fluconazole Single-Dose Tablets's effectiveness
• Anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam), buspirone, carbamazepine, cyclophosphamide, cyclosporine, ergot alkaloids (eg, ergotamine), haloperidol, HMG-CoA reductase inhibitors or "statins" (eg, simvastatin), hydantoins (eg, phenytoin), methadone, muscarinic antagonists (eg, solifenacin, tolterodine), narcotics (eg, codeine), ramelteon, sulfonylureas (eg, glipizide), theophylline, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Fluconazole Single-Dose Tablets.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fluconazole Single-Dose Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fluconazole Single-Dose Tablets:

Use Fluconazole Single-Dose Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Fluconazole Single-Dose Tablets by mouth with or without food.
• Take Fluconazole Single-Dose Tablets at least 2 hours before proton pump inhibitors (eg, omeprazole).
• To clear up your infection completely, take Fluconazole Single-Dose Tablets for the full course of treatment. Keep taking it even if you feel better in a few days.
• For some women, it may take longer than 24 hours for symptom relief to begin. If your symptoms have not improved within 3 to 5 days, you should call your doctor.
• Fluconazole Single-Dose Tablets is usually given only once, but if given for more than one dose and you miss a dose of Fluconazole Single-Dose Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Fluconazole Single-Dose Tablets.

Important safety information:

• Fluconazole Single-Dose Tablets may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Fluconazole Single-Dose Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Fluconazole Single-Dose Tablets has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by Fluconazole Single-Dose Tablets has not been attributed to total daily dose, length of therapy, or sex or age of patient. This type of liver damage may or may not be reversible when Fluconazole Single-Dose Tablets is stopped. If you notice any of the following symptoms, contact your doctor immediately: swollen or tender abdomen, yellowing of the eyes.
• Diabetes patients - Fluconazole Single-Dose Tablets may lower your blood sugar levels. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
• Be sure to use Fluconazole Single-Dose Tablets for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Hormonal birth control (eg, birth control pills) may not work as well while you are using Fluconazole Single-Dose Tablets. To prevent pregnancy, use an extra form of birth control (eg, condoms).
• Lab tests, such as liver and kidney function, may be performed while you use Fluconazole Single-Dose Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Fluconazole Single-Dose Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Fluconazole Single-Dose Tablets while you are pregnant. Fluconazole Single-Dose Tablets is found in breast milk. If you are or will be breast-feeding while you use Fluconazole Single-Dose Tablets, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Fluconazole Single-Dose Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in taste; diarrhea; dizziness; headache; nausea; stomach pain; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); dark urine; diarrhea; fever; hoarseness; irregular heartbeat; scaly, red skin over a large portion of the body; seizures; sore throat; swelling of your hands; unusual or severe stomach pain; unusual tiredness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include changes in behavior; convulsions; hallucinations; seizures; slowed breathing.

Store Fluconazole Single-Dose Tablets below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fluconazole Single-Dose Tablets out of the reach of children and away from pets.

General information:

• If you have any questions about Fluconazole Single-Dose Tablets, please talk with your doctor, pharmacist, or other health care provider.
• Fluconazole Single-Dose Tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Fluconazole Single-Dose Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.