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Generic Name: progesterone vaginal (proe JESS te rone VAJ in ul)
Brand Names: Crinone, Endometrin, FIRST-Progesterone VGS 200, FIRST-Progesterone VGS 400, Prochieve

What is FIRST-Progesterone VGS 100 (progesterone vaginal)?

Progesterone is a female hormone important for the regulation of ovulation and menstruation. Progesterone causes changes in the lining of your uterus, making it easier for a fertilized egg to attach to the uterus at the beginning of pregnancy. Progesterone then helps your body maintain the pregnancy.

Progesterone vaginal is used in fertility treatment as part of Assisted Reproductive Technology (ART) for women unable to get pregnant due to a lack of natural progesterone in the body.

Progesterone vaginal is also used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body.

This medication also prevents overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy.

Progesterone vaginal may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about FIRST-Progesterone VGS 100 (progesterone vaginal)?

Progesterone vaginal is sometimes given for only 6 to 12 days at a time. When used as part of fertility treatment, progesterone vaginal may be given for up to 12 weeks into a pregnancy. Following your dosing schedule is very important for this medication to be effective. Try not to miss any doses.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

What should I discuss with my healthcare provider before using FIRST-Progesterone VGS 100 (progesterone vaginal)?

• a history of stroke or blood clot;

• circulation problems;

• a hormone-related cancer such as breast or uterine cancer;

• abnormal vaginal bleeding;

• liver disease; or

• if you have recently had an incomplete or "missed" abortion.

Before using this medication, tell your doctor if you have any of the following conditions. You may not be able to use progesterone vaginal, or you may need a dosage adjustment or special tests during treatment.

• high blood pressure, heart disease, congestive heart failure;

• migraines,

• asthma;

• kidney disease;

• seizures or epilepsy;

• a history of depression; or

• diabetes.

How should I use FIRST-Progesterone VGS 100 (progesterone vaginal)?

Use this medication exactly as it was prescribed for you. Do not use larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.

Progesterone vaginal is sometimes given for only 6 to 12 days at a time. When used as part of fertility treatment, progesterone vaginal may be given for up to 12 weeks into a pregnancy. Following your dosing schedule is very important for this medication to be effective. Try not to miss any doses.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Progesterone vaginal gel should be applied directly into the vagina using only the applicator provided with the medicine.

Progesterone vaginal suppositories are made at the pharmacy and provided to you in a dispensing cup fitted with a mold and a special tool to push each suppository out through the bottom of the mold. Your pharmacist can show you how to dispense the suppositories from the mold.

Before inserting the vaginal suppository, remove the red cap throw it away. Avoid handling the suppository too long or it will begin to melt in your hand.

It is normal to have vaginal discharge for several days after using this medication. Talk with your doctor if you have concerns about any vaginal discharge.

What happens if I miss a dose?

Use the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

What should I avoid while using FIRST-Progesterone VGS 100 (progesterone vaginal)?

FIRST-Progesterone VGS 100 (progesterone vaginal) side effects

• sudden numbness or weakness, especially on one side of the body;

• sudden headache, confusion, pain behind the eyes, problems with vision, speech, or balance;

• chest pain, pounding heartbeats;

• migraine headache;

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

• swelling in your hands, ankles, or feet;

• fever, chills, body aches, flu symptoms;

• a breast lump; or

• symptoms of depression (sleep problems, weakness, mood changes).

Less serious side effects may include:

• mild nausea, vomiting, bloating, stomach cramps;

• diarrhea, constipation;

• dizziness, mild headache;

• pain in your vaginal or rectal area;

• pain during intercourse;

• loss of interest in sex;

• breast pain, swelling, or tenderness;

• joint or muscle pain;

• increased night-time urination; or

• vaginal itching or discharge.

This list is not complete and other side effects may occur. Tell your doctor about any unusual or bothersome side effect.

What other drugs will affect FIRST-Progesterone VGS 100 (progesterone vaginal)?

There may be other drugs that can affect progesterone vaginal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about progesterone.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.