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Generic Name: chlorzoxazone (klor ZOX a zone)
Brand Names: Eze D.S., Paraflex, Parafon Forte DSC, Relaxazone, Remular, Remular-S, Strifon Fort

What is Eze D.S. (chlorzoxazone)?

Chlorzoxazone is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain.

Chlorzoxazone is used, along with rest and physical therapy, to treat injuries and other painful muscular conditions.

Chlorzoxazone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Eze D.S. (chlorzoxazone)?

Who should not take Eze D.S. (chlorzoxazone)?

How should I take Eze D.S. (chlorzoxazone)?

Take chlorzoxazone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Chlorzoxazone is usually taken three or four times a day. Follow your doctor's instructions.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Symptoms of a chlorzoxazone overdose include nausea, vomiting, diarrhea, drowsiness, dizziness, extreme weakness, and irregular breathing.

What should I avoid while taking Eze D.S. (chlorzoxazone)?

Eze D.S. (chlorzoxazone) side effects

• an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

• liver damage (yellowing of the skin or eyes, nausea, abdominal pain or discomfort, unusual bleeding or bruising, severe fatigue); or

• stomach damage (black, bloody, or tarry stools, blood in vomit).

Other, less serious side effects may be more likely to occur. Continue to take chlorzoxazone and talk to your doctor if you experience

• drowsiness, dizziness, or lightheadedness;

• discolored urine; or

• a rash or unusual bruising.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Eze D.S. (chlorzoxazone)?

Many drugs can increase the effects of chlorzoxazone, which can lead to heavy sedation. Before taking this medication, tell your doctor if you are taking any of the following medicines:

• antihistamines such as brompheniramine (Dimetane, Bromfed, others), chlorpheniramine (Chlor-Trimeton, Teldrin, others), azatadine (Optimine), clemastine (Tavist), and many others;

• narcotics (pain killers) such as meperidine (Demerol), morphine (MS Contin, MSIR, others), propoxyphene (Darvon, Darvocet), hydrocodone (Lorcet, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), and codeine (Fiorinal, Fioricet, Tylenol #3, others);

• sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal), and secobarbital (Seconal);

• phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), and trifluoperazine (Stelazine); or

• antidepressants such as doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), phenelzine (Nardil), and tranylcypromine (Parnate).

Drugs other than those listed here may also interact with chlorzoxazone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

• Your pharmacist has more information about chlorzoxazone written for health professionals that you may read.

What does my medication look like?

Chlorzoxazone is available with a prescription under the brand name Parafon Forte DSC. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Parafon Forte DSC 500 mg--light-green, capsule-shaped tablets

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.