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Generic Name: chlorpheniramine, methscopolamine, and phenylephrine (klor fen IR a meen, meth skoe POL a meen, fen il EFF rin)
Brand Names: Aerohist Plus, Ah-Chew, Chlor-Mes, Dallergy, Denaze, Duradryl, Durahist PE, DuraTan PE, Extendryl Chews, Histatab PH, Liqui-Allergy, Norel SD, Omnihist L.A., Ralix, Redur-PCM, Rescon MX

What is Extendryl Chews (chlorpheniramine, methscopolamine, and phenylephrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Methscopolamine is an anticholinergic (an-tye-kol-in-URJ-ik) that has a drying effect on the nasal passages.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, methscopolamine, and phenylephrine is used to treat runny nose, sneezing, itchy throat, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Chlorpheniramine, methscopolamine, and phenylephrine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Extendryl Chews (chlorpheniramine, methscopolamine, and phenylephrine)?

Before using this medicine, tell your doctor if you have heart disease, high blood pressure, or a heart rhythm disorder, circulation problems, glaucoma, diabetes, a thyroid disorder, kidney disease, or problems with urination.

What should I discuss with my health care provider before taking Extendryl Chews (chlorpheniramine, methscopolamine, and phenylephrine)?

Before using this medication, tell your doctor if you are allergic to any drugs, or if you have:

• heart disease, high blood pressure, or a heart rhythm disorder;

• a blood vessel disorder or circulation problems;

• glaucoma;

• diabetes;

• a thyroid disorder;

• kidney disease;

• asthma;

• an enlarged prostate; or

• problems with urination.

Artificially-sweetened liquid forms of cold medicine may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take Extendryl Chews (chlorpheniramine, methscopolamine, and phenylephrine)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Cold medicine is usually taken for only a short time until your symptoms clear up.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. The suspension liquid form should be shaken well just before you measure a dose.

The chewable tablet must be chewed completely before you swallow it.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

What should I avoid while taking Extendryl Chews (chlorpheniramine, methscopolamine, and phenylephrine)?

Avoid becoming overheated or dehydrated during exercise and in hot weather.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice.

Extendryl Chews (chlorpheniramine, methscopolamine, and phenylephrine) side effects

• fast, pounding, or uneven heartbeat;

• confusion, hallucinations, unusual thoughts or behavior;

• severe dizziness, anxiety, restless feeling, or nervousness;

• urinating less than usual or not at all;

• easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;

• increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure); or

• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Keep using the medication and talk with your doctor if you have any of these less serious side effects:

• blurred vision;

• dry mouth;

• nausea, stomach pain, constipation;

• mild loss of appetite;

• dizziness, drowsiness, headache;

• problems with memory or concentration;

• ringing in your ears;

• restlessness or excitability (especially in children);

• warmth, tingling, or redness under your skin;

• cold feeling in your hands or feet;

• sleep problems (insomnia); or

• skin rash or itching.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Extendryl Chews (chlorpheniramine, methscopolamine, and phenylephrine)?

Before taking this medication, tell your doctor if you are using any other antihistamine or decongestant pills, liquids, or nasal sprays. Also tell your doctor if you are using any of the following drugs:

• pramlintide (Symlin);

• aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);

• an antidepressant such as amitriptyline (Elavil, Etrafon) or desipramine (Norpramin);

• bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);

• a diuretic (water pill), or medicines to treat high blood pressure, angina (chest pain), or other heart conditions;

• medication to treat irritable bowel syndrome;

• medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), risperidone (Risperdal), trazodone (Desyrel);

• migraine headache medication such as sumatriptan (Imitrex), naratriptan (Amerge), zolmitriptan (Zomig), ergotamine (Ergostat, Ergomar); or

• seizure medication such as carbamazepine (Carbatrol) or phenobarbital (Luminal, Solfoton).

If you are using any of these drugs, you may not be able to use chlorpheniramine, methscopolamine, and phenylephrine, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect chlorpheniramine, methscopolamine, and phenylephrine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist has information about chlorpheniramine, methscopolamine, and phenylephrine written for health professionals that you may read.

What does my medication look like?

Chlorpheniramine, methscopolamine, and phenylephrine is available with a prescription under many different brand names. Generic forms may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.